Evidence map›Paper›PMID 29317810›Full record

ReviewInternational journal of chronic obstructive pulmonary disease2018

Inhaled therapies in patients with moderate COPD in clinical practice: current thinking.

Amnon Ariel, Alan Altraja, Andrey Belevskiy, Piotr W Boros, Edvardas Danila, Matjaz Fležar, Vladimir Koblizek, Zvi G Fridlender, Kosta Kostov, Alvils Krams and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 16 institutions in 15 countries.

Amnon ArielEmek Medical Center, Clalit Healthcare Services, Afula, Israel.
Alan AltrajaDepartment of Pulmonary Medicine, University of Tartu.
Andrey BelevskiyDepartment of Pulmonology, Russian National Research Medical University, Moscow, Russia.
Piotr W BorosLung Pathophysiology Department, National TB and Lung Diseases Research Institute, Warsaw, Poland.
Edvardas DanilaClinic of Infectious Chest Diseases, Dermatovenereology, and Allergology, Vilnius University, Centre of Pulmonology and Allergology, Vilnius University Hospital, Vilnius, Lithuania.
Matjaz FležarUniversity Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.
Vladimir KoblizekDepartment of Pneumology, University Hospital, Hradec Králové, Czech Republic.
Zvi G FridlenderInstitute of Pulmonary Medicine, Hadassah Medical Center, Jerusalem, Israel.
Kosta KostovClinic of Pulmonary Diseases, Military Medical Academy, Sofia, Bulgaria.
Alvils KramsMedical Faculty of Latvian University, Riga East University Hospital, Riga, Latvia.
Branislava MilenkovicClinic for Pulmonary Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Attila SomfayDepartment of Pulmonology, University of Szeged, Deszk, Hungary.
Ruzena TkacovaDepartment of Respiratory Medicine and Tuberculosis, Faculty of Medicine, PJ Safarik University, Košice, Slovakia.
Neven TudoricSchool of Medicine, Dubrava University Hospital, Zagreb, Croatia.
Ruxandra UlmeanuMarius Nasta Institute of Pneumology, Bucharest, Romania.
Arschang ValipourDepartment of Respiratory and Critical Care Medicine, Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria.
Emek Medical Center · ILHadassah Medical Center · ILInstitutul de Pneumoftiziologie "Marius Nasta" · ROLudwig Boltzmann Institute for Lung Health · ATLung Institute · USMilitary Medical Academy · BGPirogov Russian National Research Medical University · RURiga East University Hospital · LVTartu University Hospital · EEUniversity Clinic of Pulmonary and Allergic Diseases Golnik · SIUniversity Hospital Dubrava · HRUniversity Hospital Hradec Králové · CZUniversity of Belgrade · RSUniversity of Pavol Jozef Šafárik · SKUniversity of Szeged · HUVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COPD is a complex, heterogeneous condition. Even in the early clinical stages, COPD carries a significant burden, with breathlessness frequently leading to a reduction in exercise capacity and changes that correlate with long-term patient outcomes and mortality. Implementation of an effective management strategy is required to reduce symptoms, preserve lung function, quality of life, and exercise capacity, and prevent exacerbations. However, current clinical practice frequently differs from published guidelines on the management of COPD. This review focuses on the current scientific evidence and expert opinion on the management of moderate COPD: the symptoms arising from moderate airflow obstruction and the burden these symptoms impose, how physical activity can improve disease outcomes, the benefits of dual bronchodilation in COPD, and the limited evidence for the benefits of inhaled corticosteroids in this disease. We emphasize the importance of maximizing bronchodilation in COPD with inhaled dual-bronchodilator treatment, enhancing patient-related outcomes, and enabling the withdrawal of inhaled corticosteroids in COPD in well-defined patient groups.

Indexed as

Administration, InhalationAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsDisease ProgressionExercise ToleranceHealth StatusHumansLungMuscarinic AntagonistsPulmonary Disease, Chronic ObstructiveQuality of LifeRecovery of FunctionRisk FactorsSeverity of Illness IndexTreatment OutcomeAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsMuscarinic Antagonistsanticholinergicdual bronchodilationinhaled corticosteroidLABALAMAtiotropium

Identifiers

PMID29317810
PMCPMC5743110
OpenAlexW2779292347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.