Evidence map›Paper›PMID 29317772›Full record

SynthesisProstate cancer and prostatic diseases2018

Processed and raw tomato consumption and risk of prostate cancer: a systematic review and dose-response meta-analysis.

Joe L Rowles, Katherine M Ranard, Catherine C Applegate, Sookyoung Jeon, Ruopeng An, John W Erdman

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Prostate cancer and prostatic diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joe L RowlesDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-0716-4759
Katherine M RanardDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Catherine C ApplegateDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Sookyoung JeonDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ruopeng AnDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
John W ErdmanDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA. JWErdman@illinois.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer (PCa) is the second most frequently diagnosed cancer among men worldwide. Many epidemiological studies have found an inverse association between increased tomato consumption and PCa risk. This study aims to determine the associations between consumption of various types of tomato products and PCa risk and to investigate potential dose-response relationships.

methodsWe conducted a systematic review and dose-response meta-analysis of dietary tomato in relation to PCa. Eligible studies were published before April 10, 2017 and were identified from PubMed, Web of Science, and the Cochrane Library. We estimated pooled risk ratios (RRs) and 95% confidence intervals (CI) using random and fixed effects models. Linear and nonlinear dose-response relationships were also evaluated for PCa risk.

resultsThirty studies related to tomato consumption and PCa risk were included in the meta-analysis, which summarized data from 24,222 cases and 260,461 participants. Higher total tomato consumption was associated with a reduced risk of PCa (RR = 0.81, 95% CI: 0.71-0.92, p = 0.001). Specifically, tomato foods (RR = 0.84, 95% CI: 0.72-0.98, p = 0.030) and cooked tomatoes and sauces (RR = 0.84, 95% CI: 0.73-0.98, p = 0.029) were associated with a reduced risk of PCa. However, no associations were found for raw tomatoes (RR = 0.96, 95% CI: 0.84-1.09, p = 0.487). There was a significant dose-response association observed for total tomato consumption (p = 0.040), cooked tomatoes and sauces (p < 0.001), and raw tomatoes (p = 0.037), but there was not a significant association with tomato foods (p

conclusionsOur data demonstrate that increased tomato consumption is inversely associated with PCa risk. These findings were accompanied with dose-response relationships for total tomato consumption and for cooked tomatoes and sauces. Further studies are required to determine the underlying mechanisms of these associations.

Indexed as

Feeding BehaviorHumansMaleProstatic NeoplasmsSolanum lycopersicum

Identifiers

PMID29317772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.