Evidence map›Paper›PMID 29317753›Full record

ArticleScientific reports2018

Influences of mesoporous magnesium calcium silicate on mineralization, degradability, cell responses, curcumin release from macro-mesoporous scaffolds of gliadin based biocomposites.

Sicheng Wang, Zhengrong Gu, Zhiwei Wang, Xiao Chen, Liehu Cao, Liang Cai, Quan Li, Jie Wei, Jung-Woog Shin, Jiacan Su

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Sicheng WangDepartment of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Zhengrong GuDepartment of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Zhiwei WangDepartment of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Xiao ChenDepartment of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Liehu CaoDepartment of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Liang CaiKey Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China.
Quan LiDepartment of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Jie WeiKey Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China.
Jung-Woog ShinDepartment of Biomedical Engineering, Inje University, Gimhae, 621749, Republic of Korea.
Jiacan SuDepartment of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. jiacansu@126.com.
Changhai Hospital · CNEast China University of Science and Technology · CNSecond Military Medical University · CNInje University · KRZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macro-mesoporous scaffolds based on wheat gliadin (WG)/mesoporous magnesium calcium silicate (m-MCS) biocomposites (WMC) were developed for bone tissue regeneration. The increasing amount of m-MCS significantly improved the mesoporosity and water absorption of WMC scaffolds while slightly decreased their compressive strength. With the increase of m-MCS content, the degradability of WMC scaffolds was obviously enhanced, and the decrease of pH value could be slow down after soaking in Tris-HCl solution for different time. Moreover, the apatite mineralization ability of the WMC scaffolds in simulated body fluid (SBF) was obviously improved with the increase of m-MCS content, indicating good bioactivity. The macro-mesoporous WMC scaffolds containing m-MCS significantly stimulated attachment, proliferation and differentiation of MC3T3-E1 cells, indicating cytocompatibility. The WMC scaffold containing 40 w% m-MCS (WMC40) possessed the highest porosity (including macroporosity and mesoporosity), which loaded the highest amount of curcumin (CU) as well as displayed the slow release of CU. The results suggested that the incorporation of m-MCS into WG produced biocomposite scaffolds with macro-mesoporosity, which significantly improved water absorption, degradability, bioactivity, cells responses and load/sustained release of curcumin.

Indexed as

AnimalsAnti-Bacterial AgentsCalcium CompoundsCell AdhesionCell DifferentiationCell LineCell ProliferationCompressive StrengthCurcuminDrug LiberationGliadinMagnesium CompoundsMicePorositySilicatesStaphylococcus aureusAnti-Bacterial AgentsCalcium Compoundscalcium silicateCurcuminGliadinMagnesium CompoundsSilicates

Identifiers

PMID29317753
PMCPMC5760662
OpenAlexW2782534597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.