ArticleScientific reports2018
Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Occlusal disharmony attenuates inhibitory synaptic transmission in the medial prefrontal cortex and contributes to anxiety.Biomedical journal · 2026Article
- A soft diet attenuates exercise-induced increases in cortical bone density and formation in long bones in growing mice.Scientific reports · 2026Article
- Xanthine oxidase inhibitor allopurinol preserves cardiac function after experimental malocclusion induced by occlusal disharmony in mice.The journal of physiological sciences : JPS · 2025Article
- Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in mice.Scientific reports · 2023Article
- Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice.Frontiers in neuroscience · 2023Article
- Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice.The journal of physiological sciences : JPS · 2022Article
- Effects of Induced Malocclusion on Vertebral Alignment in Rats: A Controlled Study by CBCTs.Animals : an open access journal from MDPI · 2021Article
- Comparison of cerebral cortex activation induced by tactile stimulation between natural teeth and implants.Journal of clinical and experimental dentistry · 2020Article
- Effects of occlusal disharmony on susceptibility to atrial fibrillation in mice.Scientific reports · 2020Article
- Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice.PloS one · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive exposure to glucocorticoids causes osteoporosis in children and adults. Occlusal disharmony is known to induce an increase in serum corticosteroid levels in murine models, but the influence of occlusal disharmony-induced stress on the bone mass during the growth period has not yet been clarified. The purpose of this study was to investigate whether occlusal disharmony-induced stress decreases bone mass. Five-week-old C57BL/6J male mice were used. A 0.5-mm increase in the vertical height of occlusion was used to induce occlusal disharmony for a period of 7 days. Serum corticosterone levels were significantly higher on post-induction day 7, with radiological evidence of osteopenia of the third lumbar vertebra and long bones of the hind limbs. Osteopenia was associated with a reduction of the mechanical properties of the tibia and femur, with significant suppression of bone formation parameters and an increase in bone resorption parameters, as evaluated by bone histomorphometric analysis of the tibial/femur metaphysis. Our findings at the level of bones were supported by our assessment of serum markers of systemic metabolism. Therefore, occlusal disharmony-induced stress may lead to osteopenia and reduce the mechanical strength of bone through an increase in serum glucocorticoid levels in mice.
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