ArticleScientific reports2018
The synergistic bactericidal effect of vancomycin on UTMD treated biofilm involves damage to bacterial cells and enhancement of metabolic activities.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Ultrasound-responsive microbubbles in refractory infection niches: multi-front targeting of microenvironmental tolerance and local delivery of toxicity-limited antibiotics.Frontiers in cellular and infection microbiology · 2026Article
- Ultrasound-responsive drug-carrying microbubbles combined with piezoelectric porous titanium scaffolds for the treatment of infected bone defects.Materials today. Bio · 2025Article
- Nanoplastics-mediated physiologic and genomic responses in pathogenic Escherichia coli O157:H7.Journal of nanobiotechnology · 2025Article
- Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection.Cell chemical biology · 2023Article
- Advances in Penile Prosthesis Surgery: A Clinical Update.Turkish journal of urology · 2022Article
- Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Advances in the Sensing and Treatment of Wound Biofilms.Angewandte Chemie (International ed. in English) · 2022Review
- Advances in the Sensing and Treatment of Wound Biofilms.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Review
- Harnessing ultrasound-stimulated phase change contrast agents to improve antibiotic efficacy against methicillin-resistantBiofilm · 2021Article
- Ultrasonic technologies in imaging and drug delivery.Cellular and molecular life sciences : CMLS · 2021Review
- Recalcitrant Staphylococcus aureus Infections: Obstacles and Solutions.Infection and immunity · 2021Review
- Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.Ultrasound in medicine & biology · 2020Review
- Ultrasound-mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge.Microbial biotechnology · 2020Review
- Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections.Ultrasound in medicine & biology · 2020Review
- Acoustic Parameters for Optimal Ultrasound-Triggered Release from Novel Spinal Hardware Devices.Ultrasound in medicine & biology · 2020Article
- Population Pharmacokinetics of Vancomycin in Kidney Transplant Recipients: Model Building and Parameter Optimization.Frontiers in pharmacology · 2020Article
- Ultrasound-triggered antibiotic release from PEEK clips to prevent spinal fusion infection: Initial evaluations.Acta biomaterialia · 2019Article
- Synergistic antibacterial effect of ultrasound microbubbles combined with chitosan-modified polymyxin B-loaded liposomes on biofilm-producingInternational journal of nanomedicine · 2019Article
- Silica-gentamicin nanohybrids: combating antibiotic resistance, bacterial biofilms, and in vivo toxicity.International journal of nanomedicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the synergistic effect of vancomycin, a cell wall synthesis inhibitor, and ultrasound-targeted microbubble destruction (UTMD), on cell viability of Staphylococcus epidermidis, embedded in biofilm, was investigated. Biofilms are the leading causes of antibiotic-resistant bacterial infections of medical implants and prosthetics worldwide. The antibiotic-resistant nature of biofilm-embedded pathogens poses a critical challenge to the medical community. Previously, studies have demonstrated the efficacy of using ultrasound waves and UTMD in circumventing this problem. However, the mechanism(s) underlying this phenomenon was not clear. Here, the present study showed that both ultrasound and UTMD damaged the cell wall structure of S. epidermidis, and floccules and fragments from damaged cells were observed on transmission electron microscope micrograph. However, the cell membrane integrity was not seriously affected by treatments, and the treatment increased the metabolic activity levels of the dormant biofilm-embedded bacteria, detected by confocal laser scanning microscope and flow cytometry, which could make them susceptible to the effect of the antibiotic. Thus, the biological mechanism underlying the efficacy of the combined treatment involving UTMD and vancomycin in the case of S. epidermidis biofilm was dissected, which may be utilized for further investigations on other biofilm pathogens before clinical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.