Evidence map›Paper›PMID 29317685›Full record

ArticleScientific reports2018

Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.

Sara M Parigi, Paulo Czarnewski, Srustidhar Das, Christiane Steeg, Leonie Brockmann, Sara Fernandez-Gaitero, Victor Yman, Marianne Forkel, Charlotte Höög, Jenny Mjösberg and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Sara M ParigiImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.
Paulo CzarnewskiImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8150-4021
Srustidhar DasImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.
Christiane SteegDepartment of Immunology, Bernhard-Nocht-Institut for Tropical Medicine, Hamburg, Germany.
Leonie BrockmannDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sara Fernandez-GaiteroImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.
Victor YmanUnit of Infectious Diseases, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.
Marianne ForkelCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Charlotte HöögUnit for Inflammation, Gastroenterology and Rheumathology, Department of Medicine, Huddinge, Sweden.
Jenny MjösbergCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Lisa WesterbergDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2943-2192
Anna FärnertUnit of Infectious Diseases, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.
Samuel HuberDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thomas JacobsDepartment of Immunology, Bernhard-Nocht-Institut for Tropical Medicine, Hamburg, Germany.
Eduardo J VillablancaImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden. eduardo.villablanca@ki.se.ORCID http://orcid.org/0000-0001-9522-9729
Karolinska Institutet · SEKarolinska University Hospital · SEBernhard Nocht Institute for Tropical Medicine · DEUniversität Hamburg · DEIntegrated Cardio Metabolic Centre · SELinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A common helper-like innate lymphoid precursor (CHILP) restricted to the innate lymphoid cells (ILC) lineage has been recently characterized. While specific requirements of transcription factors for CHILPs development has been partially described, their ability to sense cytokines and react to peripheral inflammation remains unaddressed. Here, we found that systemic increase in Flt3L levels correlated with the expansion of Lineage (Lin)

Indexed as

AnimalsBiomarkersBone Marrow CellsDisease Models, AnimalHumansImmunity, InnateInflammatory Bowel DiseasesIntegrinsLymphocyte SubsetsLymphoid Progenitor CellsMelanoma, ExperimentalMembrane ProteinsMiceNeoplasmsBiomarkersflt3 ligand proteinintegrin alpha4beta7IntegrinsMembrane Proteins

Identifiers

PMID29317685
PMCPMC5760642
OpenAlexW2781500522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.