Evidence map›Paper›PMID 29317663›Full record

ArticleScientific reports2018

TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder.

Luke Grundy, Donna M Daly, Christopher Chapple, David Grundy, Russ Chess-Williams

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

  1. Bladder mucosal afferents detect UTI and aid pathogen clearance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. A novel role for TRPV1 in macrophage giant cell formation.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Luke GrundyCentre for Urology Research, Faculty of Health Science and Medicine, Bond University, Gold Coast, Queensland, 4229, Australia.
Donna M DalyDepartment of Pharmacy and Biomedical Science, University of Central Lancashire, Preston, PR1 2HE, UK.
Christopher ChappleRoyal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.
David GrundyDepartment of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
Russ Chess-WilliamsCentre for Urology Research, Faculty of Health Science and Medicine, Bond University, Gold Coast, Queensland, 4229, Australia. rchesswi@bond.edu.au.
Bond University · AURoyal Hallamshire Hospital · GBSouth Australian Health and Medical Research Institute · AUUniversity of Central Lancashire · GBUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been implicated in mechanosensation during bladder filling. The aim of this study was to determine possible interactions between these receptors in modulating afferent nerve activity. In wildtype (TRPV1

Indexed as

Adenosine TriphosphateAnimalsCapsaicinCells, CulturedGanglia, SpinalMaleMiceMice, Inbred C57BLNeurons, AfferentPurinergic P2X Receptor AgonistsReceptors, Purinergic P2XTRPV Cation ChannelsUrinary BladderUrotheliumAdenosine TriphosphateCapsaicincapsazepinePurinergic P2X Receptor AgonistsReceptors, Purinergic P2XTRPV1 protein, mouseTRPV Cation Channels

Identifiers

PMID29317663
PMCPMC5760578
OpenAlexW2781797595

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.