SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

40 citing papers in PubMed, 60 citations in OpenAlex.

1. Subcellular sirtuin signaling networks: pivotal regulators of cardiovascular homeostasis and remodeling.Journal of molecular histology · 2026
   Review
2. SIRT6 enhances the therapeutic potential of extracellular vesicles in mitigating osteoarthritis in rat models.Stem cell research & therapy · 2026
   Article
3. NF-κB signaling as a critical inflammatory node in pulmonary arterial hypertension: from vascular remodeling to right heart failure.Frontiers in immunology · 2026
   Review
4. The association of the SIRT6 rs117385980 variant with frailty and longevity: an exploratory study.Scientific reports · 2025
   Article
5. Astragaloside IV Improves Diabetic Kidney Disease by Regulating NLRP3 Inflammasome.Journal of diabetes research · 2025
   Review
6. SIRT6 alleviates senescence induced by Porphyromonas gingivalis in human gingival fibroblasts.Molecular biology reports · 2024
   Article
7. SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs.Cardiovascular toxicology · 2024
   Review
8. Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane.PLoS biology · 2024
   Article
9. Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma.PeerJ · 2024
   Article
10. Research progress of SIRTs activator resveratrol and its derivatives in autoimmune diseases.Frontiers in immunology · 2024
    Review
11. Frontiers in medicine · 2023
    Article
12. Serum SIRT6 Levels Are Associated with Frailty in Older Adults.The journal of nutrition, health & aging · 2023
    Article
13. The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitus.Frontiers in physiology · 2023
    Review
14. SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases.Aging and disease · 2022
    Review
15. Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance.Nature reviews. Molecular cell biology · 2022
    Review
16. SIRT6 promotes ferroptosis and attenuates glycolysis in pancreatic cancer through regulation of the NF-κB pathway.Experimental and therapeutic medicine · 2022
    Article
17. Monoubiquitination in Homeostasis and Cancer.International journal of molecular sciences · 2022
    Review
18. Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice models.Genes & diseases · 2022
    Article
19. Targeting NAD+: is it a common strategy to delay heart aging?Cell death discovery · 2022
    Review
20. Histone Lysine Methylation Modification and Its Role in Vascular Calcification.Frontiers in endocrinology · 2022
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

19 authors at 9 institutions in 4 countries.

Funding

Abstract

Indexed as