ArticleTranslational psychiatry2018
Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- The role of high-amplitude bursts of high-gamma activity in naturalistic speech and music listening.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- L-Dopa-induced changes in aperiodic bursts dynamics relate to individual clinical improvement in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Critical dynamics arise during structured information presentation within embodied in vitro neuronal networks.Nature communications · 2023Article
- The contribution of gamma bursting to spontaneous gamma activity in schizophrenia.Frontiers in human neuroscience · 2023Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.BMC genomics · 2021Article
- Guanosine ameliorates positive symptoms of schizophreniaAmerican journal of translational research · 2021Article
- [Advances on GABAergic interneurons in autism spectrum disorders].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Review
- Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1aBiological psychiatry · 2020Article
- Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?Frontiers in pharmacology · 2020Review
- P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia.Frontiers in molecular neuroscience · 2020Article
- The scale-invariant, temporal profile of neuronal avalanches in relation to cortical γ-oscillations.Scientific reports · 2019Article
- Neuronal Avalanches in Input and Associative Layers of Auditory Cortex.Frontiers in systems neuroscience · 2019Article
- Article
- On the safety of repeated ketamine infusions for the treatment of depression: Effects of sex and developmental periods.Neurobiology of stress · 2018Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resemble those seen in schizophrenic patients. However, the altered network dynamics underlying these cognitive impairments largely remain to be characterized, especially at the cellular level. Here, we use in vivo two-photon calcium imaging to describe pathological dynamics, occurring in parallel with cognitive dysfunction, in a developmental NMDA receptor hypofunction model. We observed increased synchrony and specific alterations in spatiotemporal activity propagation, which could be causally linked to a previously unidentified persistent bursting phenotype. This phenotype was rescued by acute treatment with the NMDA receptor co-agonist D-serine or the GABA
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