ArticleTranslational psychiatry2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- Intervening After Trauma: Child-Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration.Psychological science · 2024Article
- Childhood Maltreatment and Longitudinal Epigenetic Aging: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.European journal of psychotraumatology · 2024Article
- Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood.Clinical epigenetics · 2023Article
- Child Maltreatment and Long-Term Physical and Mental Health Outcomes: An Exploration of Biopsychosocial Determinants and Implications for Prevention.Child psychiatry and human development · 2023Review
- A Comprehensive Review on Multifaceted Mechanisms Involved in the Development of Breast Cancer Following Adverse Childhood Experiences (ACEs).International journal of environmental research and public health · 2022Review
- Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children.International journal of molecular sciences · 2022Article
- Evaluating the challenges and reproducibility of studies investigating DNA methylation signatures of psychological stress.Epigenomics · 2022Review
- Article
- Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis.Forensic sciences research · 2021Review
- Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes.Frontiers in neuroscience · 2020Article
- DNA methylation of NR3c1 in infancy: Associations between maternal caregiving and infant sex.Infant mental health journal · 2019Article
- [Environment and epigenetics].Der Nervenarzt · 2019Review
Corrections and comments
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Authors and funding
18 authors at 9 institutions in 4 countries.
Funding
Abstract
This study reveals the influence of child maltreatment on DNA methylation across the genome and provides the first evidence that a psychosocial intervention program, the Nurse Family Partnership (NFP), which targets mothers at risk for abusive parenting, associates with variation in the DNA methylome in adult offspring. The 188 participants were born to women randomly assigned to control (n = 99) or nurse-visited intervention groups (n = 89) and provided blood samples and a diagnostic interview at age 27 years. Interindividual variation in the blood DNA methylome was described using principal components (PC) scores derived from principal component analysis and showed that the NFP program (PC10: p = 0.029) and a history of abuse/neglect (PC1: p = 0.029, PC2: p = 0.009) significantly associated with DNA methylome variation at 27 years of age independent of gender, ancestry, cellular heterogeneity, and a polygenic risk index for major psychiatric disorders. The magnitude of the association between child maltreatment and DNA methylation was reduced when accounting for lifestyle factors, including smoking. These findings reflect the sustained impact of both childhood adversity as well as intervention programs that target such adversity on the epigenome but highlight the need for prospective longitudinal studies of DNA methylome variation in the context of early intervention programs.
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