Evidence map›Paper›PMID 29317494›Full record

ArticleThe Journal of biological chemistry2018

Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP

Junghoon Ha, Yu Xu, Takeharu Kawano, Tyler Hendon, Lia Baki, Sumanta Garai, Andreas Papapetropoulos, Ganesh A Thakur, Leigh D Plant, Diomedes E Logothetis

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Oxidation Driven Reversal of PIPFunction (Oxford, England) · 2023
    Article
  7. Role of hydrogen sulfide in subarachnoid hemorrhage.CNS neuroscience & therapeutics · 2022
    Review
  8. Review
  9. Regulation of Ion Channel Function by Gas Molecules.Advances in experimental medicine and biology · 2021
    Review
  10. Article
  11. Article
  12. Gas Signaling Molecules and Mitochondrial Potassium Channels.International journal of molecular sciences · 2018
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Junghoon HaFrom the Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298.
Yu XuDepartment of Pharmaceutical Sciences in the School of Pharmacy, Northeastern University Bouvé College of Health Sciences, Boston, Massachusetts 02115.
Takeharu KawanoDepartment of Pharmaceutical Sciences in the School of Pharmacy, Northeastern University Bouvé College of Health Sciences, Boston, Massachusetts 02115.
Tyler HendonFrom the Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298.
Lia BakiDepartment of Pharmaceutical Sciences in the School of Pharmacy, Northeastern University Bouvé College of Health Sciences, Boston, Massachusetts 02115.
Sumanta GaraiDepartment of Pharmaceutical Sciences in the School of Pharmacy, Northeastern University Bouvé College of Health Sciences, Boston, Massachusetts 02115.
Andreas Papapetropoulosthe Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens 157 71, Greece, and.
Ganesh A ThakurDepartment of Pharmaceutical Sciences in the School of Pharmacy, Northeastern University Bouvé College of Health Sciences, Boston, Massachusetts 02115.
Leigh D PlantDepartment of Pharmaceutical Sciences in the School of Pharmacy, Northeastern University Bouvé College of Health Sciences, Boston, Massachusetts 02115.
Diomedes E LogothetisFrom the Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, d.logothetis@northeastern.edu.
Northeastern University · USVirginia Commonwealth University · USBiomedical Research Foundation of the Academy of Athens · GR

Funding

Structural Determinants of PIP2 RegulationR01HL059949 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Leigh Daniel Plant · 1998 to 2026
$11.6M
NHLBI NIH HHS R01 HL059949
6 · The paper itself

Abstract

Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain, and other peripheral tissues. Phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

Models, MolecularAllosteric RegulationAmino Acid SubstitutionAnimalsCHO CellsCricetulusCystathionine gamma-LyaseG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHydrogen SulfideMiceMolecular Dynamics SimulationMutagenesis, Site-DirectedMutationOocytesPatch-Clamp TechniquesPhosphatidylinositol 4,5-DiphosphateCystathionine gamma-LyaseG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHydrogen SulfidePhosphatidylinositol 4,5-DiphosphatePotassium Channels, Inwardly RectifyingRecombinant Fusion ProteinsRecombinant Proteinssodium bisulfideSulfidesgasotransmittersGIRK channelshydrogen sulfideinwardly rectifying K+ (Kir) channelsischemiaKATP channelsKir3Kir3 or GIRK channelsphosphatidylinositol 4,5-bisphosphate (PIP2)phosphoinositidepotassium channelstroke

Identifiers

PMID29317494
PMCPMC5846148
OpenAlexW2783292685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.