Evidence map›Paper›PMID 29317451›Full record

ArticleDiabetes care2018

Duration of Diabetes and Prediabetes During Adulthood and Subclinical Atherosclerosis and Cardiac Dysfunction in Middle Age: The CARDIA Study.

Jared P Reis, Norrina B Allen, Michael P Bancks, J Jeffrey Carr, Cora E Lewis, Joao A Lima, Jamal S Rana, Samuel S Gidding, Pamela J Schreiner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Jared P ReisDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD reisjp@mail.nih.gov.ORCID 0000-0002-9435-9481
Norrina B AllenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Michael P BancksDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
J Jeffrey CarrDepartment of Radiology and Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN.
Cora E LewisDivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Joao A LimaSchool of Medicine, The Johns Hopkins University, Baltimore, MD.
Jamal S RanaDivision of Research, Kaiser Permanente Northern California, Oakland, CA.ORCID 0000-0002-8222-3958
Samuel S GiddingNemours Cardiac Center, A.I. DuPont Hospital for Children, Wilmington, DE.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN.
Northwestern University · USDuPont (United States) · USJohns Hopkins University · USKaiser Permanente · USNational Heart Lung and Blood Institute · USUniversity of Alabama at Birmingham · USUniversity of Minnesota · USVanderbilt University · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
RESEARCH TRAINING IN CVD EPIDEMIOLOGY AND PREVENTIONT32HL069771 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Mercedes Renee Carnethon · 2003 to 2026
$5.9M
NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS T32 HL069771NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

objectiveTo determine whether the duration of diabetes and duration of prediabetes estimated during a 25-year period in early adulthood are each independently associated with coronary artery calcified plaque (CAC) and abnormalities in left ventricular structure and function later in life. RESEARCH DESIGN AND

methodsParticipants were 3,628 white and black adults aged 18-30 years without diabetes or prediabetes at baseline (1985-1986) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Durations of diabetes and prediabetes were estimated based on their identification at examinations 7, 10, 15, 20, and 25 years later. CAC was identified by computed tomography at years 15, 20, and 25. Left ventricular structure and function were measured via echocardiogram at year 25.

resultsOf the 3,628 individuals, 12.7% and 53.8% developed diabetes and prediabetes, respectively; average (SD) duration was 10.7 (10.7) years and 9.5 (5.4) years. After adjustment for sociodemographic characteristics and other cardiovascular risk factors, and mutual adjustment for each other, the hazard ratio for the presence of CAC was 1.15 (95% CI 1.06, 1.25) and 1.07 (1.01, 1.13) times higher for each 5-year-longer duration of diabetes and prediabetes, respectively. Diabetes and prediabetes duration were associated with worse subclinical systolic function (longitudinal strain [

conclusionsDurations of diabetes and prediabetes during adulthood are both independently associated with subclinical atherosclerosis and left ventricular systolic and diastolic dysfunction in middle age.

Indexed as

AdolescentAdultAsymptomatic DiseasesAtherosclerosisCardiovascular DiseasesCoronary Artery DiseaseDiabetes MellitusDiabetic AngiopathiesDisease ProgressionEchocardiographyFemaleHeart VentriclesHumansLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID29317451
PMCPMC5860835
OpenAlexW2782658100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.