Evidence map›Paper›PMID 29317436›Full record

ArticleDiabetes2018

The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.

Xi Chen, Iriscilla Ayala, Chris Shannon, Marcel Fourcaudot, Nikhil K Acharya, Christopher P Jenkinson, Sami Heikkinen, Luke Norton

Abstract read
In one paragraph

Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Reduced Growth and Inflammation in Lrp5Journal of cellular and molecular medicine · 2025
    Article
  10. Association ofDiagnostics (Basel, Switzerland) · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Whole-Genome Resequencing Reveals Signatures of Adaptive Evolution inAnimals : an open access journal from MDPI · 2024
    Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xi ChenDiabetes Division, University of Texas Health Science Center, San Antonio, TX.
Iriscilla AyalaDiabetes Division, University of Texas Health Science Center, San Antonio, TX.
Chris ShannonDiabetes Division, University of Texas Health Science Center, San Antonio, TX.
Marcel FourcaudotDiabetes Division, University of Texas Health Science Center, San Antonio, TX.
Nikhil K AcharyaDiabetes and Obesity Center of Excellence, University of Washington, Seattle, WA.
Christopher P JenkinsonSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Harlingen, TX.
Sami HeikkinenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Luke NortonDiabetes Division, University of Texas Health Science Center, San Antonio, TX nortonl@uthscsa.edu.ORCID 0000-0002-0231-5722
The University of Texas Health Science Center at San Antonio · USThe University of Texas Rio Grande Valley · USUniversity of Eastern Finland · FIUniversity of Washington · US

Funding

Novel Mechanisms Regulating the Adipocyte-Brain-Hepatocyte AxisP01DK088761 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GORDILLO, RUTH · 2010 to 2019
$17.4M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
The role of TCF7L2 in hepatic glucose metabolism in vivoK01DK098314 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI NORTON, LUKE · 2014 to 2016
$329k
NIDDK NIH HHS K01 DK098314NIDDK NIH HHS P01 DK088761NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637
6 · The paper itself

Abstract

The gene encoding for transcription factor 7-like 2 (

Indexed as

3T3-L1 CellsAdipocytesAdipogenesisAnimalsBlotting, WesternCase-Control StudiesCell DifferentiationDiabetes Mellitus, Type 2Down-RegulationFemaleGlucoseGlucose IntoleranceHumansInsulin ResistanceIn Vitro TechniquesLiverGlucoseRNA, MessengerTCF7L2 protein, humanTcf7l2 protein, mouseTranscription Factor 7-Like 2 Protein

Identifiers

PMID29317436
PMCPMC5860863
OpenAlexW2784128628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.