ArticleNeuroImage2018
Double dissociation of structure-function relationships in memory and fluid intelligence observed with magnetic resonance elastography.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Mechanical properties of the developing brain in a model of fetal alcohol spectrum disorders and relationships to perineuronal net integrity.Brain research · 2026Article
- Brain mechanics and cognition: the role of rodent MR elastography in identifying cellular mechanisms.Frontiers in cognition · 2026Article
- Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.Brain communications · 2026Article
- Hippocampal relational memory and spatial reconstruction: where are we at and where are we bound?Frontiers in cognition · 2026Review
- Brain age prediction and early neurodegeneration detection using contrastive learning on brain biomechanics: a retrospective, multicentre study.EBioMedicine · 2025Article
- Putamen Stiffness Declines with Age and Is Associated with Implicit Sequence Learning Outcomes.Brain sciences · 2025Article
- Mechanical Properties of the Cortex in Older Adults and Relationships With Personality Traits.Human brain mapping · 2025Article
- MRI-based whole-brain elastography and volumetric measurements to predict brain age.Biology methods & protocols · 2025Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Acute effects of high-intensity exercise on brain mechanical properties and cognitive function.Brain imaging and behavior · 2024Article
- The contributions of relative brain viscosity to brain function and health.Brain communications · 2024Review
- Associations between vascular health, brain stiffness and global cognitive function.Brain communications · 2024Article
- Transversely-isotropic brain in vivo MR elastography with anisotropic damping.Journal of the mechanical behavior of biomedical materials · 2023Article
- Article
- Structure-Function Dissociations of Human Hippocampal Subfield Stiffness and Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- OSCILLATE: A low-rank approach for accelerated magnetic resonance elastography.Magnetic resonance in medicine · 2022Article
- Mechanical Properties of the Developing Brain are Associated with Language Input and Vocabulary Outcome.Developmental neuropsychology · 2022Article
- Relationships between aggression, sensation seeking, brain stiffness, and head impact exposure: Implications for head impact prevention in ice hockey.Brain and behavior · 2022Article
- Mapping heterogenous anisotropic tissue mechanical properties with transverse isotropic nonlinear inversion MR elastography.Medical image analysis · 2022Article
- Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography.Physics in medicine and biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Brain tissue mechanical properties, measured in vivo with magnetic resonance elastography (MRE), have proven to be sensitive metrics of neural tissue integrity. Recently, our group has reported on the positive relationship between viscoelasticity of the hippocampus and performance on a relational memory task in healthy young adults, which highlighted the potential of sensitive MRE measures for studying brain health and its relation to cognitive function; however, structure-function relationships outside of the hippocampus have not yet been explored. In this study, we examined the relationships between viscoelasticity of both the hippocampus and the orbitofrontal cortex and performance on behavioral assessments of relational memory and fluid intelligence. In a sample of healthy, young adults (N = 53), there was a significant, positive relationship between orbitofrontal cortex viscoelasticity and fluid intelligence performance (r = 0.42; p = .002). This finding is consistent with the previously reported relationship between hippocampal viscoelasticity and relational memory performance (r = 0.41; p = .002). Further, a significant double dissociation between the orbitofrontal-fluid intelligence relationship and the hippocampal-relational memory relationship was observed. These data support the specificity of regional brain MRE measures in support of separable cognitive functions. This report of a structure-function relationship observed with MRE beyond the hippocampus suggests a future role for MRE as a sensitive neuroimaging technique for brain mapping.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.