Evidence map›Paper›PMID 29317265›Full record

ArticleThe Journal of investigative dermatology2018

Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis.

Christian F Guerrero-Juarez, Aliaksandr A Astrowski, Rabi Murad, Christina T Dang, Vera O Shatrova, Aksana Astrowskaja, Chae Ho Lim, Raul Ramos, Xiaojie Wang, Yuchen Liu and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Christian F Guerrero-JuarezDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA.
Aliaksandr A AstrowskiDepartment of Medical Biology and Genetics, Grodna State Medical University, Grodna, Belarus.
Rabi MuradDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA.
Christina T DangDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Vera O ShatrovaDepartment of Medical Biology and Genetics, Grodna State Medical University, Grodna, Belarus.
Aksana AstrowskajaDepartment of Medical Biology and Genetics, Grodna State Medical University, Grodna, Belarus.
Chae Ho LimThe Ronald O. Perelman Department of Dermatology, Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Raul RamosDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA.
Xiaojie WangDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA.
Yuchen LiuDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Hye-Lim LeeDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Kim T PhamDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Tsai-Ching HsiDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Ji Won OhDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA; Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea; Hair Transplantation Center, Kyungpook National University Hospital, Daegu, Republic of Korea.
Daniel CrockerDepartment of Biology, Sonoma State University, Rohnert Park, California, USA.
Ali MortazaviDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA.
Mayumi ItoThe Ronald O. Perelman Department of Dermatology, Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Maksim V PlikusDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA. Electronic address: plikus@uci.edu.
University of California, Irvine · USGrodno State Medical University · BYNew York University · USSonoma State University · US

Funding

MINORITY BIOMEDICAL RESEARCHERS PROGRAMR25GM055246 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOTA-BRAVO, LUIS M · 1996 to 2022
$15.3M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Cutaneous Biology and Skin Disease Training ProgramT32AR064184 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ORLOW, SETH J. · 2014 to 2024
$2.1M
Induction of fat regeneration in skin wounds by hair follicle signalingR01AR067273 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PLIKUS, MAKSIM V · 2014 to 2018
$1.9M
Skin Defense by Dermal AdipocytesR01AR069653 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L · 2016 to 2020
$1.9M
Induction of digit regeneration by Wnt active nail epitheliumR01AR066022 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ITO, MAYUMI · 2014 to 2018
$1.9M
NCI NIH HHS T32 CA009054NIAMS NIH HHS R01 AR066022NIAMS NIH HHS R01 AR067273NIAMS NIH HHS R01 AR069653NIAMS NIH HHS T32 AR064184NIGMS NIH HHS R25 GM055246
6 · The paper itself

Abstract

Large excisional wounds in mice prominently regenerate new hair follicles (HFs) and fat, yet humans are deficient for this regenerative behavior. Currently, wound-induced regeneration remains a clinically desirable, but only partially understood phenomenon. We show that large excisional wounds in rats across seven strains fail to regenerate new HFs. We compared wound transcriptomes between mice and rats at the time of scab detachment, which coincides with the onset of HF regeneration in mice. In both species, wound dermis and epidermis share core dermal and epidermal transcriptional programs, respectively, yet prominent interspecies differences exist. Compared with mice, rat epidermis expresses distinct transcriptional and epigenetic factors, markers of epidermal repair, hyperplasia, and inflammation, and lower levels of WNT signaling effectors and regulators. When recombined on the surface of excisional wounds with vibrissa dermal papillae, partial-thickness skin grafts containing distal pelage HF segments, but not interfollicular epidermis, readily regenerated new vibrissa-like HFs. Together, our findings establish rats as a nonregenerating rodent model for excisional wound healing and suggest that low epidermal competence and associated transcriptional profile may contribute to its regenerative deficiency. Future comparison between rat and mouse may lend further insight into the mechanism of wounding-induced regeneration and causes for its deficit.

Indexed as

RegenerationAnimalsCell DifferentiationDisease Models, AnimalEpidermal CellsGene Expression ProfilingHair FollicleHumansMiceMorphogenesisRatsRats, Inbred BNRats, Inbred BUFRats, Inbred F344Rats, Long-EvansRats, Sprague-Dawley

Identifiers

PMID29317265
PMCPMC6059613
OpenAlexW2782421618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.