Evidence map›Paper›PMID 29317193›Full record

ArticleExperimental neurology2018

An essential role for neuregulin-4 in the growth and elaboration of developing neocortical pyramidal dendrites.

Blanca Paramo, Sean Wyatt, Alun M Davies

Open access · hybridAbstract read
In one paragraph

Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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  12. Neuregulins in Neurodegenerative Diseases.Frontiers in aging neuroscience · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Blanca ParamoSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, Wales, UK.
Sean WyattSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, Wales, UK.
Alun M DaviesSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, Wales, UK. Electronic address: daviesalun@cf.ac.uk.
Cardiff University · GB

Funding

Wellcome Trust 103852
6 · The paper itself

Abstract

Neuregulins, with the exception of neuregulin-4 (NRG4), have been shown to be extensively involved in many aspects of neural development and function and are implicated in several neurological disorders, including schizophrenia, depression and bipolar disorder. Here we provide the first evidence that NRG4 has a crucial function in the developing brain. We show that both the apical and basal dendrites of neocortical pyramidal neurons are markedly stunted in Nrg4

Indexed as

NeocortexAge FactorsAnimalsCell Culture TechniquesDendritesEmbryo, MammalianEmpty Spiracles Homeobox ProteinsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHomeodomain ProteinsMiceMice, KnockoutMicrotubule-Associated ProteinsNeuregulinsPyramidal CellsReceptor, ErbB-4Empty Spiracles Homeobox ProteinsErbb4 protein, mouseGreen Fluorescent ProteinsHomeodomain ProteinsMicrotubule-Associated ProteinsMtap2 protein, mouseneuregulin-4NeuregulinsReceptor, ErbB-4RNA, MessengerTranscription FactorsCortical pyramidal neuronDendriteDevelopmentKnockout mouseNeuregulin

Identifiers

PMID29317193
PMCPMC5866123
OpenAlexW2781718629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.