ArticleReproductive biology and endocrinology : RB&E2018
Physiological, mitochondrial, and oxidative stress differences in the presence or absence of lactation in rats.
Article in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of lactation on postpartum pelvic floor muscle regeneration in preclinical model.npj women's health · 2025Article
- Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.Journal of the American Heart Association · 2023Review
- Mitochondrial Bioenergetics of Extramammary Tissues in Lactating Dairy Cattle.Animals : an open access journal from MDPI · 2021Article
- Graduate Student Literature Review: Mitochondrial adaptations across lactation and their molecular regulation in dairy cattle.Journal of dairy science · 2021Review
- Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Cardiac hypertrophy with obesity is augmented after pregnancy in C57BL/6 mice.Biology of sex differences · 2019Article
- Cellular metabolic rates and oxidative stress profiles in primary fibroblast cells isolated from virgin females, reproductively experienced females, and male Sprague-Dawley rats.Physiological reports · 2018Article
- Life History Trade-offs within the Context of Mitochondrial Hormesis.Integrative and comparative biology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHuman epidemiological data show that breastfeeding reduces the mother's probability of developing several disease conditions, including obesity and type II diabetes compared to mothers that give birth but do not breastfeed. The goal of this investigation was to characterize how lactation changes a rat's body composition, metabolism, mitochondrial function, and oxidative stress.
methodsTen-week old female Sprague-Dawley rats were divided into three groups (n = 8 per group): 1) non-reproductive (NR), 2) those that were allowed to mate and give birth, but were not allowed to suckle their pups (PP), and 3) those that were allowed to mate and give birth, and suckled their young until weaning at 21 days (PL). All animals were sacrificed at a time corresponding to 7 days following the weaning of pups (i.e., day 28 postpartum).
resultsThe body mass of PL rats was similar to NR rats, but the body mass of PP rats was higher than NR rats. Importantly, PL rats had lower retroperitoneal white adipose tissue mass compared to both NR and PP rats. The difference in fat mass was accompanied by higher protein levels of PPARδ, SOD2, and reduced oxidative damage. Furthermore, the liver of PL rats had higher mitochondrial function with NADH-linked substrates, and higher expression of PGC-1α, PPARδ, and SOD2.
conclusionsThese acute differences observed between female rats that did and did not suckle their young could be used as the foundation for future research investigating the prolonged and sustained benefits of lactation.
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Registered trials
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