Evidence map›Paper›PMID 29316908›Full record

Trial reportBMC complementary and alternative medicine2018

Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study.

Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan, Areg Hovhannisyan

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02390349 ("CuraMed" and "Curamin" in Osteoarthritis), which is not on this map. Cited by 77 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 17 pooled it
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02390349 nacompletednot on this map

"CuraMed" and "Curamin" in Osteoarthritis

TypeinterventionalSponsorEuroPharma, Inc.Ran2015 to 2016Enrolled179ConditionsOsteoarthritis, KneeArmsPlacebo, Curamin, CuraMed
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 17 syntheses or guidelines pooled it, 241 citations in OpenAlex.

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  9. Efficacy and Safety of Curcumin andFrontiers in immunology · 2022
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Armine Haroyan"Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia. rheumo_arm@yahoo.com.
Vahan Mukuchyan"Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia.
Nana Mkrtchyan"Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia.
Naira Minasyan"Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia.
Srbuhi Gasparyan"Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia.
Aida Sargsyan"Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia.
Mikael NarimanyanYerevan State Medical University of Armenia, Koryun 2, 0025, Yerevan, Armenia.
Areg HovhannisyanAnti-doping Service of Republican Centre of Sport Medicine, Acharyan Str., 2/6, Yerevan, Armenia.
Erebouni Medical Center · AMYerevan State Medical University · AM

Funding

EuroPharma USA Inc 2012-01
6 · The paper itself

Abstract

backgroundThe aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA).

methodsThe effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial. Primary outcome efficacy measures included OA physical function performance-based tests, the WOMAC recommended index of joint pain, morning stiffness, limitations of physical function, and the patients' global assessment of disease severity.

resultsFavorable effects of both preparations compared to placebo were observed after only 3 months of continuous treatment. A significant effect of Curamin® compared to placebo was observed both in physical performance tests and the WOMAC joint pain index, while superior efficacy of CuraMed vs placebo was observed only in physical performance tests. The effect size compared to placebo was comparable for both treatment groups but was superior in the Curamin® group. The treatments were well tolerated.

conclusionsTwelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. Curcumin in combination with boswellic acid is more effective. Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects of curcumin and boswellic acid.

trial registrationThis trial is registered at the database www.clinicaltrials.gov . https://clinicaltrials.gov/ct2/show/NCT02390349?term=EuroPharma&rank=1 . Study registration number: NCT02390349 .

Indexed as

CurcuminTriterpenesAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedOsteoarthritisRange of Motion, Articularboswellic acidCurcuminTriterpenes

Identifiers

PMID29316908
PMCPMC5761198
OpenAlexW2783826729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.