Evidence map›Paper›PMID 29316840›Full record

ArticlePharmaceutical biology2018

Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways.

Kiran Kumar Soni, Li Tao Zhang, Bo Ram Choi, Keshab Kumar Karna, Jae Hyung You, Yu Seob Shin, Sung Won Lee, Chul Young Kim, Chen Zhao, Han-Jung Chae and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

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  19. Evidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Kiran Kumar Sonia Department of Urology , Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University , Jeonju , Republic of Korea.
Li Tao Zhanga Department of Urology , Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University , Jeonju , Republic of Korea.
Bo Ram Choia Department of Urology , Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University , Jeonju , Republic of Korea.
Keshab Kumar Karnaa Department of Urology , Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University , Jeonju , Republic of Korea.
Jae Hyung Youa Department of Urology , Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University , Jeonju , Republic of Korea.
Yu Seob Shina Department of Urology , Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University , Jeonju , Republic of Korea.
Sung Won Leeb Department of Urology , Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
Chul Young Kimc College of Pharmacy , Hanyang University , Ansan , Republic of Korea.
Chen Zhaod Department of Urology , Renji Hospital, Shanghai Jiao Tong University School of Medicine, and Shanghai Institute of Andrology , Shanghai , China.
Han-Jung Chaee Department of Pharmacology , Chonbuk University of Medical School , Jeonju , Republic of Korea.
Hye Kyung Kimf College of Pharmacy , Kyungsung University , Busan , Republic of Korea.
Jong Kwan Parka Department of Urology , Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University , Jeonju , Republic of Korea.ORCID http://orcid.org/0000-0001-9682-2081
Jeonbuk National University · KRHanyang University · KRKyungsung University · KRSamsung Medical Center · KRShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextMOTILIPERM was prepared as a mixture of extracts of three medicinal herbs [roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae)].

objectiveTo investigate the role of reactive oxygen species (ROS)-based endoplasmic reticulum (ER) stress in a rat model of varicocele and the therapeutic efficacy of MOTILIPERM in this model. MATERIALS AND

methodsSixty male rats were divided into five experimental groups: a normal control group (CTR + vehicle), a control group administered MOTILIPERM 200 mg/kg (CTR + M 200), a varicocele-induced control group (VC + vehicle) and two varicocele-induced groups administered MOTILIPERM 100 (VC + M 100) or 200 (VC + M 200) mg/kg for 4 weeks. Testis weights were recorded and serums were assayed for hormone concentrations. Tissues were subjected to semen analysis, histopathology, analyses of ER response protein expression levels and oxidative stress were assessed by measuring ROS, reactive nitrogen species (RNS), malondialdehyde (MDA) level and ratios of total glutathione (GSH)/oxidized GSH (GSSG).

resultsMOTILIPERM treatment of varicocele-induced groups significantly increased left testis weight, testosterone level, sperm motility, count and spermatogenic cell density. ER-response protein expression levels were dose-dependently decreased in VC + M 200 group compared with VC + vehicle group. MOTILIPERM treatment also decreased MDA and ROS/RNS level but increased GSH/GSSG ratio. DISCUSSION AND

conclusionsThis study suggests that ROS-related ER stress may play a major role in varicocele-induced infertility and MOTILIPERM, a novel compound targeting ROS-based ER stress, may be therapeutically useful in treatment of varicocele, or as a supplement for the treatment of infertility.

Indexed as

AnimalsAntioxidantsEndoribonucleasesJNK Mitogen-Activated Protein KinasesMaleMultienzyme ComplexesPhosphorylationPlant ExtractsProtein Serine-Threonine KinasesRatsRats, Sprague-DawleyReactive Oxygen SpeciesSignal TransductionTestisVaricoceleAntioxidantsEndoribonucleasesErn1 protein, ratJNK Mitogen-Activated Protein KinasesMultienzyme ComplexesPlant ExtractsProtein Serine-Threonine KinasesReactive Oxygen SpeciesER stressoxidative stressSpermtestosterone

Identifiers

PMID29316840
PMCPMC6130442
OpenAlexW2783969394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.