ArticleInternational journal of molecular sciences2018
Impaired Skin Barrier Due to Sebaceous Gland Atrophy in the Latent Stage of Radiation-Induced Skin Injury: Application of Non-Invasive Diagnostic Methods.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Novel dermis niche equivalent based on a 3D-structure fabricated by 2-photon polymerization.Biomaterials and biosystems · 2026Article
- Single-cell analysis of 2,3,7,8-tetrachlorodibenzo-bioRxiv : the preprint server for biology · 2026Article
- Recent advances in understanding of radiation-induced skin tissue reactions with respect to acute tissue injury and late adverse effect.Journal of radiation research · 2025Review
- Effect of standard skin care treatments on skin barrier function in X-irradiated hairless mice.Asia-Pacific journal of oncology nursing · 2023Article
- Objective Skin Quality Assessment after Reconstructive Procedures for Facial Skin Defects.Journal of clinical medicine · 2022Article
- The circadian clock protects against acute radiation-induced dermatitis.Toxicology and applied pharmacology · 2020Article
- Clinical Effect of Moisturized Skin Care on Radiation Dermatitis of Head and Neck Cancer.In vivo (Athens, Greece)Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation-induced skin injury can take the form of serious cutaneous damage and have specific characteristics. Asymptomatic periods are classified as the latent stage. The skin barrier plays a critical role in the modulation of skin permeability and hydration and protects the body against a harsh external environment. However, an analysis on skin barrier dysfunction against radiation exposure in the latent stage has not been conducted. Thus, we investigated whether the skin barrier is impaired by irradiation in the latent stage and aimed to identify the molecules involved in skin barrier dysfunction. We analyzed skin barrier function and its components in SKH1 mice that received 20 and 40 Gy local irradiation. Increased transepidermal water loss and skin pH were observed in the latent stage of the irradiated skin. Skin barrier components, such as structural proteins and lipid synthesis enzymes in keratinocyte, increased in the irradiated group. Interestingly, we noted sebaceous gland atrophy and increased serine protease and inflammatory cytokines in the irradiated skin during the latent period. This finding indicates that the main factor of skin barrier dysfunction in the latent stage of radiation-induced skin injury is sebaceous gland deficiency, which could be an intervention target for skin barrier impairment.
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