Evidence map›Paper›PMID 29316516›Full record

ArticleEnvironment international2018

Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression.

Ami R Zota, Susanna D Mitro, Joshua F Robinson, Emily G Hamilton, June-Soo Park, Emily Parry, R Thomas Zoeller, Tracey J Woodruff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ami R ZotaDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington D.C., USA.
Susanna D MitroDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington D.C., USA.
Joshua F RobinsonDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
Emily G HamiltonDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
June-Soo ParkEnvironmental Chemistry Laboratory, California Department of Toxic Substances Control, Berkeley, CA, USA.
Emily ParryEnvironmental Chemistry Laboratory, California Department of Toxic Substances Control, Berkeley, CA, USA.
R Thomas ZoellerBiology Department, Morrill Science Center, University of Massachusetts at Amherst, Amherst, MA, USA.
Tracey J WoodruffProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, CA, USA. Electronic address: tracey.woodruff@ucsf.edu.
University of California, San Francisco · USCalifornia Department of Toxic Substances Control · USMilken Institute · USUniversity of Massachusetts Amherst · US

Funding

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's CenterP01ES022841 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2013 to 2018
$3.9M
PCB Disruption of Thyroid Hormone Action During DevelopmentR01ES010026 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ZOELLER, ROBERT THOMAS · 2000 to 2013
$3.8M
Role of endocrine-disrupting chemicals and social stress on perinatal outcomesR00ES019881 · NIEHS · GEORGE WASHINGTON UNIVERSITY · PI ZOTA, AMI R · 2013 to 2015
$747k
Human Maternal/Fetal Exposures to PBDEs and their Metabolites During DevelopmentR21ES022422 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2013 to 2014
$259k
NIEHS NIH HHS P01 ES022841NIEHS NIH HHS R00 ES019881NIEHS NIH HHS R01 ES010026NIEHS NIH HHS R21 ES022422
6 · The paper itself

Abstract

backgroundHuman fetal exposures to polybrominated diphenyl ethers (PBDEs) and their metabolites (OH-PBDEs) are unique from adults, and in combination with a different metabolic profile, may make fetal development more sensitive to adverse health outcomes from these exposures. However, we lack data to characterize human fetal PBDE exposures and the metabolic factors that can influence these exposures.

objectiveWe examined differences between 2nd trimester maternal and fetal exposures to PBDEs and OH-PBDEs. We also characterized fetal cytochrome P450 (CYP) mRNA expression and its associations with PBDE exposures.

methodsWe collected paired samples of maternal serum and fetal liver (n=86) with a subset having matched placenta (n=50). We measured PBDEs, OH-PBDEs, and mRNA expression of CYP genes (e.g. CYP1A1, -2E1, -2J2, -2C9) in all samples. As a sensitivity analysis, we measured PBDEs and OH-PBDEs in umbilical cord serum from a subset (n=22).

resultsBDE-47 was detected in ≥96% of all tissues. Unadjusted ∑PBDEs concentrations were highest in fetal liver (geometric mean (GM)=0.72ng/g), whereas lipid-adjusted concentrations were highest in cord serum (111.12ng/g lipid). In both cases, fetal concentrations were approximately two times higher than maternal serum levels (GM=0.33ng/g or 48.75ng/g lipid). ΣOH-PBDEs were highest in maternal and cord sera and 20-200 times lower than PBDE concentrations. In regression models, maternal BDE-47 explained more of the model variance of liver than of placenta BDE-47 concentrations (adjusted R

conclusionOur findings suggest that under normal conditions of mid-gestation, the human fetus is directly exposed to concentrations of PBDEs that may be higher than previously estimated based on maternal serum and that these exposures are associated with the expression of mRNAs coding for CYP enzymes. These results will help frame and interpret findings from studies that use maternal or cord blood as proxy measures of fetal exposures, and will inform the molecular pathways by which PBDEs affect human health.

Indexed as

FetusMaternal ExposureCytochrome P-450 Enzyme SystemFemaleHalogenated Diphenyl EthersHumansHydroxylationLiverPregnancyCytochrome P-450 Enzyme SystemHalogenated Diphenyl EthersBrominated flame retardantsCytochrome P-450 enzymesEndocrine disruptersFetal metabolismOH-PBDEsOrganohalogen chemicalsPlacenta transportPrenatal exposures

Identifiers

PMID29316516
PMCPMC6561508
OpenAlexW2781803153

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.