Evidence map›Paper›PMID 29316274›Full record

ArticlePigment cell & melanoma research2018

Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions.

Yuan Lu, Mikki Boswell, William Boswell, Susanne Kneitz, Michael Hausmann, Barbara Klotz, Janine Regneri, Markita Savage, Angel Amores, John Postlethwait and 3 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Pigment cell & melanoma research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. Transcriptional background effects on a tumor driver gene in different pigment cell types of medaka.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yuan LuThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.ORCID 0000-0002-2420-4804
Mikki BoswellThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
William BoswellThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Susanne KneitzPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Michael HausmannPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Barbara KlotzPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Janine RegneriPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Markita SavageThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Angel AmoresInstitute of Neuroscience, University of Oregon, Eugene, OR, USA.
John PostlethwaitInstitute of Neuroscience, University of Oregon, Eugene, OR, USA.
Wesley WarrenThe Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Manfred SchartlPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Ronald WalterThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Texas State University · USUniversity of Würzburg · DEUniversity of Oregon · USWashington University in St. Louis · US

Funding

Enhanced Development of the Xiphophorus Model System R24-OD-011120R24OD011120 · OD · TEXAS STATE UNIVERSITY · PI GABOR, CAITLIN, LU, YUAN · 2012 to 2019
$5.3M
Development of Aquatic Model Resources for Therapeutic ScreensR24OD018555 · OD · UNIVERSITY OF OREGON · PI POSTLETHWAIT, JOHN H. · 2014 to 2017
$2.6M
Advancing the Scientific Potential of Transcriptomics in Aquatic ModelsR24OD011199 · OD · UNIVERSITY OF OREGON · PI CRESKO, WILLIAM A, POSTLETHWAIT, JOHN H. · 2012 to 2014
$1.8M
NIH HHS R24 OD011120NIH HHS R24 OD011199NIH HHS R24 OD018555
6 · The paper itself

Abstract

Comparative analysis of human and animal model melanomas can uncover conserved pathways and genetic changes that are relevant for the biology of cancer cells. Spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny may be informative in identifying genes and functional pathways that are similarly related to melanoma development in all vertebrates, including humans. To assess functional pathways involved in the Xiphophorus melanoma, we performed gene expression profiling of the melanomas produced in interspecies BC

Indexed as

CyprinodontiformesFish ProteinsGene Expression Regulation, NeoplasticMelanomaNeoplasm ProteinsReceptor Protein-Tyrosine KinasesSignal TransductionTranscriptomeAnimalsFemaleHumansMaleNeoplasms, ExperimentalFish ProteinsNeoplasm ProteinsReceptor Protein-Tyrosine KinasesXmrk protein, Xiphophorusbioinformaticsgene expression profilingmelanomasignaling transductiontranscriptomeXiphophorusxmrk(EGFR)

Identifiers

PMID29316274
PMCPMC6013346
OpenAlexW2783594833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.