ArticleJournal of clinical hypertension (Greenwich, Conn.)2018
Prehypertension is a comorbid state with autonomic and metabolic dysfunction.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of combined high-intensity bodyweight interval training and breathing exercise on cardiometabolic health in normal-weight middle-aged adults with hypertension.BMC public health · 2025Trial
- Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 2024 update.The Journal of physiology · 2025Review
- Predictors of Cardiac Autonomic Dysfunction in Obesity-Related Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study.Biomedical journal · 2023Article
- Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis-A Systematic Review and Meta-Analysis.Neurology international · 2023Review
- Obesity-related hypertension and chronic kidney disease: from evaluation to management.Kidney research and clinical practice · 2023Article
- The Modulation of Arachidonic Acid Metabolism and Blood Pressure-Lowering Effect of Honokiol in Spontaneously Hypertensive Rats.Molecules (Basel, Switzerland) · 2022Article
- Prevalence of high blood pressure and high normal blood pressure among 7- to 17-year-old children and adolescents in developed regions, China from 2014 to 2017: using new national blood pressure reference for Chinese children and adolescents.Journal of human hypertension · 2019Article
- Higher visceral fat rate estimated by bioelectrical impedance analysis increases risk for prehypertension in normal weight healthy adults.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Higher visceral fat rate estimated by bioelectrical impedance analysis increases risk for prehypertension in normal weight healthy adults.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Article
- Prehypertension is a comorbid state with autonomic and metabolic dysfunction.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to elucidate the role of autonomic dysfunction in the context of complex metabolic and cardiovascular changes in subjects with prehypertension. We identified 556 asymptomatic subjects without hypertension who underwent comprehensive cardiovascular exams. We obtained heart rate recovery (HRR) after peak exercise to quantitatively measure autonomic dysfunction. Of the 556 participants, 279 individuals had prehypertension and the remaining 277 had optimal BP. HRR was significantly lower in the prehypertension group (36.0 ± 14.5 bpm) than in the optimal BP group (39.3 ± 14.7 bpm, P = .009). The prehypertension group more frequently demonstrated features of metabolic disturbances and subclinical target organ damage. Among the various baseline cardiovascular and metabolic factors assessed, resting systolic BP and high-density lipoprotein cholesterol level were independent determinants of HRR (both P < .05). Autonomic dysfunction coexists with prehypertension and is closely linked to changes in systolic BP and lipid metabolism.
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