ArticleAngewandte Chemie (International ed. in English)2018
An Oxygen-Tolerant PET-RAFT Polymerization for Screening Structure-Activity Relationships.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Oxygen-Tolerant Photo-Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA-ATRP) for High-Throughput Synthesis of Polymer Bioconjugates.Angewandte Chemie (International ed. in English) · 2026Article
- Self-driving lab for the data-driven design of single-chain polymer nanoparticles.Cell press blue · 2026Article
- A robotic approach to polymerisation kinetics: a case study on copolymerisation parameter estimation.Chemical science · 2026Article
- Article
- Dual-Pathway Strategy for Click-Type Functionalization and Programmable Polymer Deconstruction.Macromolecules · 2026Article
- Gene Delivery Mediated by Backbone-Degradable RAFT Copolymers.Biomacromolecules · 2026Article
- Red-Light-Induced PET-RAFT Polymerization to Afford (Meth)acrylamide-Based Poly(Macromolecules · 2026Article
- Polyanion Chemistry Engineers Ternary RNA Nanoparticle Structure/Function from the Inside-Out.ACS nano · 2026Article
- Red Light-Driven, Oxygen-Tolerant RAFT Polymerization Enabled by Methylene Blue.Journal of the American Chemical Society · 2025Article
- Leveraging reactivity to gain precise control over macromolecular structures with photocatalysis in reversible-deactivation radical polymerizations.Chemical science · 2025Review
- Self-Assembly of Amorphous 2D Polymer Nanodiscs with Tuneable Size, pH-Responsive Degradation and Controlled Drug Release.Angewandte Chemie (International ed. in English) · 2025Article
- Data-Driven Design of Novel Polymer Excipients for Pharmaceutical Amorphous Solid Dispersions.Bioconjugate chemistry · 2024Article
- Aerobic mechanochemical reversible-deactivation radical polymerization.Nature communications · 2024Article
- Open-Air Chemical Recycling: Fully Oxygen-Tolerant ATRP Depolymerization.Journal of the American Chemical Society · 2024Article
- Aqueous photo-RAFT polymerization under ambient conditions: synthesis of protein-polymer hybrids in open air.Chemical science · 2024Article
- Controlled switching thiocarbonylthio end-groups enables interconvertible radical and cationic single-unit monomer insertions and RAFT polymerizations.Nature communications · 2024Article
- Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections.Nature communications · 2023Article
- Red-Light-Driven Atom Transfer Radical Polymerization for High-Throughput Polymer Synthesis in Open Air.Journal of the American Chemical Society · 2023Article
- Tyrosine residues initiated photopolymerization in living organisms.Nature communications · 2023Article
- A User's Guide to Machine Learning for Polymeric Biomaterials.ACS polymers Au · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The complexity of polymer-protein interactions makes rational design of the best polymer architecture for any given biointerface extremely challenging, and the high throughput synthesis and screening of polymers has emerged as an attractive alternative. A porphyrin-catalysed photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerisation was adapted to enable high throughput synthesis of complex polymer architectures in dimethyl sulfoxide (DMSO) on low-volume well plates in the presence of air. The polymerisation system shows remarkable oxygen tolerance, and excellent control of functional 3- and 4-arm star polymers. We then apply this method to investigate the effect of polymer structure on protein binding, in this case to the lectin concanavalin A (ConA). Such an approach could be applied to screen the structure-activity relationships for any number of polymer-protein interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.