ArticleBipolar disorders2018
Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.
Article in Bipolar disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Grading of glioma and prediction of IDH mutation status via longitudinal relaxation time in rotating frame mapping on 5-T magnetic resonance imaging: added value to amide proton transfer-weighted imaging.Quantitative imaging in medicine and surgery · 2026Article
- Sex-specific associations of episode type in bipolar I disorder with neuro-metabolic lateralization of the cortico-striatal-cerebellar (CSC) circuit.BMC psychiatry · 2025Article
- Deletion of the Voltage-Gated Calcium Channel Gene, CaCerebellum (London, England) · 2025Article
- SNP-associated differential methylation inEpigenomics · 2025Article
- A double-blind, randomized, sham-controlled clinical trial of cerebellar intermittent theta burst stimulation for bipolar disorder: Safety, tolerability, mood and cognitive effects.Transcranial magnetic stimulation (2024) · 2025Article
- Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia.Translational psychiatry · 2024Article
- Review
- Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I.Journal of affective disorders · 2023Article
- Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study.Cerebellum (London, England) · 2023Article
- Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Functional Connectivity of the Cerebellar Vermis in Bipolar Disorder and Associations with Mood.bioRxiv : the preprint server for biology · 2023Article
- Neurobiological Markers for Predicting Treatment Response in Patients with Bipolar Disorder.Biomedicines · 2022Article
- Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.Brain imaging and behavior · 2022Article
- Metabolic abnormalities in the basal ganglia and cerebellum in bipolar disorder: A multi-modal MR study.Journal of affective disorders · 2022Article
- Grey and white matter alteration in euthymic children with bipolar disorder: a combined source-based morphometry (SBM) and voxel-based morphometry (VBM) study.Brain imaging and behavior · 2022Article
- Comparison of Cerebellar Grey Matter Alterations in Bipolar and Cerebellar Patients: Evidence from Voxel-Based Analysis.International journal of molecular sciences · 2021Article
- Quantification of brain proton longitudinal relaxation (TBipolar disorders · 2021Article
- Decreased Functional Connectivity of Vermis-Ventral Prefrontal Cortex in Bipolar Disorder.Frontiers in human neuroscience · 2021Article
- Three-Dimensional GRE TMagnetic resonance in medicine · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesQuantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors, and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients vs healthy controls that were consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality. The current study built upon this prior work to investigate brain T1ρ differences across euthymic, depressed, and manic mood states of bipolar disorder.
methodsForty participants with bipolar I disorder and 29 healthy control participants matched for age and gender were enrolled. Participants with bipolar disorder were imaged in one or more mood states, yielding 27, 12, and 13 imaging sessions in euthymic, depressed, and manic mood states, respectively. Three-dimensional, whole-brain anatomical images and T1ρ maps were acquired for all participants, enabling voxel-wise evaluation of T1ρ differences between bipolar mood state and healthy control groups.
resultsAll three mood state groups had increased T1ρ relaxation times in the cerebellum compared to the healthy control group. Additionally, the depressed and manic groups had reduced T1ρ relaxation times in and around the basal ganglia compared to the control and euthymic groups.
conclusionsThe study implicated the cerebellum and basal ganglia in the pathophysiology of bipolar disorder and its mood states, the roles of which are relatively unexplored. These findings motivate further investigation of the underlying cause of the abnormalities, and the potential role of altered metabolic activity in these regions.
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