Evidence map›Paper›PMID 29316078›Full record

ArticleJournal of viral hepatitis2018

Occult HBV infection in HIV-infected adults and evaluation of pooled NAT for HBV.

T R Dinesha, J Boobalan, S Sivamalar, D Subashini, S S Solomon, K G Murugavel, P Balakrishnan, D M Smith, S Saravanan

Abstract readEvaluation Study
In one paragraph

Article in Journal of viral hepatitis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Nested Group Testing Procedure.Communications in mathematics and statistics · 2022
    Article
  4. Article
  5. Review
  6. Article
  7. Sample pooling for SARS-CoV-2 RT-PCR screening.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Article
  8. Challenges and Controversies to Testing for COVID-19.Journal of clinical microbiology · 2020
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

T R DineshaY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
J BoobalanY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
S SivamalarY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
D SubashiniY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
S S SolomonY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
K G MurugavelY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
P BalakrishnanY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
D M SmithUniversity of California San Diego, La Jolla, CA, USA.
S SaravananY.R. Gaitonde Centre for AIDS Research and Education, Chennai, India.ORCID 0000-0002-5991-8022
YR Gaitonde Centre for AIDS Research and Education · INJohns Hopkins University · USUniversity of California San Diego · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Combined Testing to Identify Virologic Failure and HIV-1 Drug ResistanceR03EB015365 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2014 to 2015
$233k
NIAID NIH HHS P30 AI036214NIBIB NIH HHS R03 EB015365NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

The study aimed to determine the prevalence of occult hepatitis B virus infection among HIV-infected persons and to evaluate the use of a pooling strategy to detect occult HBV infection in the setting of HIV infection. Five hundred and two HIV-positive individuals were tested for HBV, occult HBV and hepatitis C and D with serologic and nucleic acid testing (NAT). We also evaluated a pooled NAT strategy for screening occult HBV infection among the HIV-positive individuals. The prevalence of HBV infection among HIV-positive individuals was 32 (6.4%), and occult HBV prevalence was 10%. The pooling HBV NAT had a sensitivity of 66.7% and specificity of 100%, compared to HBV DNA NAT of individual samples. In conclusion, this study found a high prevalence of occult HBV infection among our HIV-infected population. We also demonstrated that pooled HBV NAT is highly specific, moderately sensitive and cost-effective. As conventional HBV viral load assays are expensive in resource-limited settings such as India, pooled HBV DNA NAT might be a good way for detecting occult HBV infection and will reduce HBV-associated complications.

Indexed as

AdultDNA, ViralFemaleHepatitis BHepatitis B virusHepatitis CHepatitis DHIV InfectionsHumansIndiaMaleMolecular Diagnostic TechniquesSensitivity and SpecificitySpecimen HandlingDNA, ViralHBVHIVoccult HBVpooled NAT and resource-limited settings

Identifiers

PMID29316078
PMCPMC5980682
OpenAlexW2783892558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.