ArticleNeurogastroenterology and motility2018
Evaluating the reliability and construct validity of the Eckardt symptom score as a measure of achalasia severity.
Article in Neurogastroenterology and motility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes of Short-length vs Standard-length Myotomy Using Per-Oral Endoscopic Myotomy (POEM) for Achalasia: A Randomized Controlled Pilot Study
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Impact of myotomy length on per-oral endoscopic myotomy (POEM) outcomes for achalasia: a meta-analysis of randomized trials.Surgical endoscopy · 2025Pooled it
- ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing.The American journal of gastroenterology · 2020Guideline
- ACG Clinical Guidelines: Diagnosis and Management of Achalasia.The American journal of gastroenterology · 2020Guideline
- Pseudoachalasia: a systematic review of the literature.Esophagus : official journal of the Japan Esophageal Society · 2020Pooled it
- Reflux symptom burden and objective findings at long-term follow-up after peroral endoscopic myotomy.Surgical endoscopy · 2026Article
- Definition of Clinically Meaningful Thresholds for the Brief Esophageal Dysphagia Questionnaire and Eckardt Score: A Multicenter Psychometric Study.Neurogastroenterology and motility · 2026Article
- Effects of body position on high-resolution manometry parameters and their correlations with symptoms.Journal of clinical biochemistry and nutrition · 2026Article
- Effectiveness of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors on Esophageal Wall Thickening in Eosinophilic Esophagitis.Gut and liver · 2026Article
- Translation and cross-sectional validation of the achalasia patient reported outcomes questionnaire in a Dutch cohort.BMC gastroenterology · 2026Article
- What worsens swallowing in esophageal achalasia? Insights from patient-reported outcomes.Frontiers in nutrition · 2026Article
- Saudi Gastroenterology Association (SGA) clinical care pathway and standards of care for peroral endoscopic myotomy (POEM) in achalasia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- MULTICHANNEL INTRALUMINAL IMPEDANCE MAY BE USEFUL TO IDENTIFY CLINICALLY RELEVANT ESOPHAGOGASTRIC JUNCTION OUTFLOW OBSTRUCTION.Arquivos de gastroenterologia · 2026Article
- Laparoscopic Heller myotomy with Dor fundoplication for achalasia: an outcome in a tertiary health center of Nepal.Frontiers in surgery · 2026Article
- Development of a novel patient-oriented tool to assess achalasia symptoms and response to treatment (I-PASS, International Patient-oriented tool for Achalasia Symptom Score).Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025Article
- The Predilection of Specific Diseases to Affect Different Sections of the Esophagus.Life (Basel, Switzerland) · 2025Review
- Adding the patient perspective: the necessity of patient reported outcomes in cardiac surgery clinical trials.Current opinion in cardiology · 2025Review
- Treatment of achalasia led to normalisation of energy metabolism and proteosynthesis dependent on the pool of circulating amino acids; metabolomic monitoring and body composition analysis on insufficient nutrition.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Clinical Outcomes of Patients with Achalasia Following Pneumatic Dilation Treatment: A Single Center Experience.Journal of clinical medicine · 2025Article
- Persistent body-weight change on achalasia and peroral endoscopic myotomy: a multicenter cohort study.Journal of gastroenterology · 2025Observational
- Patient-Reported Outcome Measures in Benign Esophageal Disorders.The American journal of gastroenterology · 2025Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAchalasia is a disease of mechanical esophageal dysfunction characterized by dysphagia, chest pain, regurgitation, and malnutrition. The Eckardt symptom score (ESS) is the gold standard self-report assessment tool. Current guidelines outline a three-step approach to patient reported outcomes measure design. Developed prior to these policies, the ESS has not undergone rigorous testing of its reliability and validity.
methodsAdult achalasia patients retrospectively identified via a patient registry were grouped based on treatment history. Patients were grouped PREPOST (completed ESS, GERDQ, brief esophageal dysphagia questionnaire, NIH PROMIS Global Health, high resolution manometry, timed barium esophagram prior to treatment and after) and POST (completed measures only after treatment). Clinical characteristics, treatment type and date were obtained via medical record. Standardized psychometric analyses for reliability and construct validity were performed. KEY
results107 patients identified; 83 POST and 24 PREPOST. The ESS has fair internal consistency and split-half reliability with a single factor structure. Dysphagia accounts for half the variance in ESS, while chest pain and weight loss account for 10% each. Pre-post-surgical assessment demonstrates improvements in ESS, except for weight loss. Effect sizes range from 0.24 to 2.53, with greatest change in regurgitation. Validity of the ESS is supported by modest correlations with GERDQ, HRQOL, and physiological data. CONCLUSIONS & INFERENCES: The ESS demonstrates fair reliability and validity, with a single factor structure mostly explained by dysphagia. Based on psychometric findings, weight loss and chest pain items may be decreasing ESS reliability and validity. Further assessment of the ESS under FDA guidelines is warranted.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.