Evidence map›Paper›PMID 29315919›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2018

Prevalence and longitudinal trends of food allergy during childhood and adolescence: Results of the Isle of Wight Birth Cohort study.

D Venkataraman, M Erlewyn-Lajeunesse, R J Kurukulaaratchy, S Potter, G Roberts, S Matthews, S H Arshad

Abstract read
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Frontiers in pediatrics · 2021
    Pooled it
  4. Trial
  5. Trial
  6. Atopic outcomes at 5 years in the CORAL cohort born during the 2020 COVID-19 lockdown.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Feast for thought: A comprehensive review of food allergy 2021-2023.The Journal of allergy and clinical immunology · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. The US population-level burden of cow's milk allergy.The World Allergy Organization journal · 2022
    Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

D VenkataramanUniversity Hospitals Southampton NHS Foundation Trust, Southampton, UK.
M Erlewyn-LajeunesseUniversity Hospitals Southampton NHS Foundation Trust, Southampton, UK.
R J KurukulaaratchyUniversity Hospitals Southampton NHS Foundation Trust, Southampton, UK.
S PotterThe David Hide Asthma and Allergy Research Centre, Isle of Wight, UK.ORCID 0000-0002-9761-2227
G RobertsUniversity Hospitals Southampton NHS Foundation Trust, Southampton, UK.ORCID 0000-0003-2252-1248
S MatthewsThe David Hide Asthma and Allergy Research Centre, Isle of Wight, UK.
S H ArshadUniversity Hospitals Southampton NHS Foundation Trust, Southampton, UK.

Funding

Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescenceR01HL082925 · NHLBI · ST. MARY'S HOSPITAL NEWPORT · PI ARSHAD, SYED HASAN · 2007 to 2010
$1.7M
NHLBI NIH HHS R01 HL082925
6 · The paper itself

Abstract

backgroundThe prevalence and time trends of food allergy change during childhood depending on the age of the child and the type of food.

objectiveTo study prevalence and longitudinal trends in food allergy from birth to 18 years in an unselected birth cohort in the Isle of Wight.

methodInformation on food allergy was collected at ages 1, 2, 4, 10 and 18 years from the Isle of Wight Birth Cohort (n = 1456). Skin prick testing (SPT) was performed at the age of 1 and 2 years in symptomatic children. At 4, 10 and 18 years of age, participants were tested to a panel of food and aeroallergens. Food allergy was diagnosed based on the criteria: symptoms suggestive of a typical IgE-mediated reaction and reaction <4 hours following exposure to a known food allergen. McNemar's test was used to determine significance of changes in prevalence over time.

resultsThe prevalence of food allergy remained relatively constant in early childhood (5.3%, 4.4% and 5.0% at 1, 2 and 4 years, respectively), with significant decline at 10 years (2.3%, P < .001 vs 4 years) followed by significant rise at 18 years (4%, P = .02 vs 10 years). Cow's milk (1.6%-3.5%) and egg (1.1%-1.4%) were the most common allergens in the first 10 years with peanut (1%) and tree nuts (0.5%) becoming more prevalent beyond 10 years. Fruit and wheat allergy were less common at 10 years, and shellfish and kiwi emerged during adolescence. The prevalence of food allergy plus positive SPT was 1.3%, 0.8%, 0.8%, 0.9% and 2.2% at 1, 2, 4, 10 and 18 years, respectively.

conclusionFood allergy is highly prevalent in infancy with partial resolution during late childhood. However, a number of children acquire new food allergy during adolescence resulting in a relatively higher prevalence at 18 years.

Indexed as

AdolescentChildChild, PreschoolCohort StudiesEnglandFemaleFood HypersensitivityHumansInfantLongitudinal StudiesMalePrevalenceepidemiologyfood allergyIgEpaediatrics

Identifiers

PMID29315919
PMCPMC5869129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.