ArticleJournal of clinical laboratory analysis2018
Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population.
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2018Pooled it
- Pooled it
- SMAD3 Gene Polymorphisms and Protein Expression as Potential Biomarkers of Susceptibility to Knee Osteoarthritis.Cureus · 2026Article
- Comparative Analysis of Osteoarthritis Therapeutics: A Justification for Harnessing Retrospective Strategies via an Inverted Pyramid Model Approach.Biomedicines · 2024Review
- Association of ADAMTS-5 gene polymorphisms with the susceptibility to knee osteoarthritis in a Chinese Han population.Journal of orthopaedic surgery and research · 2024Article
- Inhibition of SMAD3 effectively reduces ADAMTS-5 expression in the early stages of osteoarthritis.BMC musculoskeletal disorders · 2023Article
- Novel association between asthma and osteoarthritis: a nationwide health and nutrition examination survey.BMC pulmonary medicine · 2021Article
- The effects of mindfulness-based stress reduction therapy combined with intensive education on the effectiveness of the care and the awareness rate in patients with arthritis and diabetes.American journal of translational research · 2021Article
- Assessment of the Role of SelectedPharmacogenomics and personalized medicine · 2021Article
- The polymorphism of SMAD3 rs1065080 is associated with increased risk for knee osteoarthritis.Molecular biology reports · 2019Article
- Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population.Journal of clinical laboratory analysis · 2018Article
- The association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis: a meta-analysis.Therapeutics and clinical risk management · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany studies have revealed that transforming growth factor-beta (TGF-β) signals play important roles in maintaining normal status of articular cartilage in human osteoarthritis (OA). However, SMAD3 had inhibitory effect on TGF-β-induced chondrocyte maturation.
methodTo evaluate the association of SMAD3 genetic variants with the risk of knee OA, we conducted this hospital-based case-control study involving 350 knee patients with OA and 400 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single-nucleotide polymorphism (SNP) Scan
resultsOur results indicate that the GG genotype of rs12901499 could decrease the risk of knee OA compared to AA genotype. However, stratified analyses by sex and age did not obtain positive findings with regard to the association between rs12901499 polymorphism and knee OA risk.
conclusionIn conclusion, SMAD3 rs12901499 polymorphism may be involved in the development of knee OA. Larger studies with more diverse ethnic populations are needed to confirm these results.
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