ArticleHepatology (Baltimore, Md.)2018
Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity.
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Article in Hepatology (Baltimore, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
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53 citing papers in PubMed, 75 citations in OpenAlex.
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- Proteomics and cytokine array jointly reveal the role of macrophage proinflammatory shift in liver fibrosis in dairy cows with ketosis.Journal of animal science and biotechnology · 2025Article
- Liver diseases: epidemiology, causes, trends and predictions.Signal transduction and targeted therapy · 2025Review
- Exploring the pharmacological mechanisms for alleviating OSA: Adenosine A2A receptor downregulation of the PI3K/Akt/HIF‑1 pathway (Review).Biomedical reports · 2025Review
- Chromium and formoterol therapy for obesity-induced asthma in rats.Frontiers in pharmacology · 2025Article
- Exploring the pathogenesis of MAFLD from an immunological perspective: from the perspective of the cGAS/STING/NF-κB signaling pathway.Frontiers in immunology · 2025Review
- HFD feeding for seven months abolishes STING disruption-driven but not female sex-based protection against hepatic steatosis and inflammation in mice.The Journal of nutritional biochemistry · 2025Article
- Purinergic Signaling in Non-Parenchymal Liver Cells.International journal of molecular sciences · 2024Review
- Article
- Inhibition of visceral adipose tissue-derived pathogenic signals by activation of adenosine AAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.Cell reports. Medicine · 2024Article
- Functional Food Chemical Ingredient Strategies for Non-alcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis: Chemical Properties, Health Benefits, Action, and Application.Current nutrition reports · 2024Review
- Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults.Arthritis research & therapy · 2024Article
- Activation of NLRP3 Inflammasome via Drp1 Overexpression in Kupffer Cells Aggravates Ischemia-reperfusion Injury in Hepatic Steatosis.Journal of clinical and translational hepatology · 2023Article
- Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma.Cell reports. Medicine · 2023Article
- Myeloid-derived growth factor alleviates non-alcoholic fatty liver disease alleviates in a manner involving IKKβ/NF-κB signaling.Cell death & disease · 2023Article
- Bidirectional Regulation of Sodium Acetate on Macrophage Activity and Its Role in Lipid Metabolism of Hepatocytes.International journal of molecular sciences · 2023Article
- Knockout of Purinergic P2YInternational journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
21 authors at 7 institutions in 2 countries.
Yuli CaiDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Honggui LiDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Mengyang LiuDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Ya PeiDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Juan ZhengDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Jing ZhouDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Xianjun LuoDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Wenya HuangDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Linqiang MaDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Qiuhua YangVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA.
Shaodong GuoDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Xiaoqiu XiaoDepartment of Endocrinology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qifu LiDepartment of Endocrinology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tianshu ZengDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Fanyin MengResearch, Central Texas Veterans Health Care System, Temple, TX.
Heather FrancisResearch, Central Texas Veterans Health Care System, Temple, TX.
Shannon GlaserResearch, Central Texas Veterans Health Care System, Temple, TX.
Lulu ChenDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yuqing HuoVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA.
Gianfranco AlpiniResearch, Central Texas Veterans Health Care System, Temple, TX.
Chaodong WuDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX.
Texas A&M University · USFirst Affiliated Hospital of Chongqing Medical University · CNPeking University · CNCentral Texas Veterans Health Care System · USHuazhong University of Science and Technology · CNTemple College · USUnion Hospital · CN
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MPFKFB3 in vascular remodelingR01HL134934 · NHLBI · AUGUSTA UNIVERSITY · PI HUO, YUQING, SU, YUNCHAO · 2017 to 2020
$2.3MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MProtective role of adenosine 2A receptor in NAFLDR01DK095862 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI WU, CHAODONG · 2013 to 2017
$1.6MThe role of adenosine kinase in atherosclerosisR01HL095556 · NHLBI · UNIVERSITY OF MINNESOTA · PI HUO, YUQING · 2011 to 2015
$1.5MRegulation of biliary growth and fibrosis by melatoninR01DK115184 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MREGULATION OF CELLULAR SENESCENCE BY NON-CODING RNAS IN ALCOHOLIC LIVER INJURYR21AA025997 · NIAAA · SCOTT AND WHITE MEMORIAL HOSPITAL · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$435kRole of stem cell derived microvesicles in alcoholic liver injuryR21AA025157 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$350kRole of Mechanosensitive Receptors During Biliary Proliferation and FibrosisI01BX002192 · VA · OLIN TEAGUE VETERANS CENTER · PI GLASER, SHANNON STROUD · 2014 to 2018
–BLRD VA I01 BX001724BLRD VA I01 BX002192NHLBI NIH HHS R01 HL095556NHLBI NIH HHS R01 HL134934NIAAA NIH HHS R21 AA025157NIAAA NIH HHS R21 AA025997NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK095862NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK115184
Abstract
Adenosine 2A receptor (A
conclusionTaken together, our results demonstrate that disruption of A
Indexed as
AnimalsCells, CulturedDiet, High-FatDisease ProgressionFemaleHepatocytesInflammationMacrophagesMaleMice, Inbred C57BLMyeloid CellsNon-alcoholic Fatty Liver DiseaseReceptor, Adenosine A2ASterol Regulatory Element Binding Protein 1Receptor, Adenosine A2ASrebf1 protein, mouseSterol Regulatory Element Binding Protein 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.