Evidence map›Paper›PMID 29315714›Full record

ArticleJournal of neuroscience research2018

Brain abnormalities in cognition, anxiety, and depression regulatory regions in adolescents with single ventricle heart disease.

Nancy A Pike, Bhaswati Roy, Ritika Gupta, Sadhana Singh, Mary A Woo, Nancy J Halnon, Alan B Lewis, Rajesh Kumar

2 registry-linked trialsOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322212 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled52ConditionsType2diabetesArmsThiamine, Placebo
NCT06326996 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled52ConditionsCoronary Heart Disease, Coronary Artery Bypass GraftingArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Review
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  11. Article
  12. Brain Structural Changes in Patients with Pulmonary Arterial Hypertension.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Cardiovascular and Stroke Nursing Council Science in Review.Journal of the American Heart Association · 2019
    Article
  17. Age-Related Increase of Insulin-Degrading Enzyme Is Inversely Correlated with Cognitive Function in APPswe/PS1dE9 Mice.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nancy A PikeUCLA School of Nursing, University of California, Los Angeles, CA, 90095, USA.
Bhaswati RoyUCLA School of Nursing, University of California, Los Angeles, CA, 90095, USA.
Ritika GuptaDepartment of Anesthesiology, University of California, Los Angeles, CA, USA.
Sadhana SinghDepartment of Anesthesiology, University of California, Los Angeles, CA, USA.
Mary A WooUCLA School of Nursing, University of California, Los Angeles, CA, 90095, USA.
Nancy J HalnonDivision of Pediatric Cardiology, University of California, Los Angeles, CA, 90095, USA.
Alan B LewisDivision of Pediatric Cardiology, Children's Hospital Los Angeles, CA, 90027, USA.
Rajesh KumarDepartment of Anesthesiology, University of California, Los Angeles, CA, USA.ORCID 0000-0001-5355-9586
University of California, Los Angeles · USChildren's Hospital of Los Angeles · US

Funding

Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart DiseaseR01NR016463 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2016 to 2019
$2.0M
Memory and Brain Structure in Adolescents with Single Ventricle Heart DiseaseR01NR013930 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIKE, NANCY ANN · 2013 to 2016
$1.4M
NINR NIH HHS R01 NR013930NINR NIH HHS R01 NR016463
6 · The paper itself

Abstract

backgroundSingle ventricle heart disease (SVHD) adolescents show cognitive impairments and anxiety and depressive symptoms, indicating the possibility of brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites in SVHD remains unclear. We examined brain tissue changes in SVHD compared to controls using T2-relaxometry procedures, which measure free water content and show tissue injury.

methodsProton-density and T2-weighted images, using a 3.0-Tesla MRI, as well as anxiety (Beck anxiety inventory [BAI]), depressive symptoms (patient health questionnaire-9 [PHQ-9]), and cognition (wide range assessment of memory and learning 2 [WRAML2] and Montreal cognitive assessment [MoCA]) data were collected from 20 SVHD (age: 15.8 ± 1.1 years, male/female: 11/9) and 36 controls (age: 16.0 ± 1.1 years, male/female: 19/17). Whole-brain T2-relaxation maps were calculated, normalized to a common space, smoothed, and compared between groups and sexes (analysis of covariance; covariates: age, sex; p < 0.001).

resultsSVHD subjects showed significantly increased BAI and PHQ-9 and reduced MoCA and WRAML2 scores over controls. Several brain regions in SVHD showed increased T2-relaxation values (chronic injury), including the cingulate, and insula, hippocampus/para-hippocampal gyrus, thalamus, hypothalamus, amygdala, frontal white matter, corpus callosum, brainstem, and cerebellar areas. Decreased T2-relaxation values (acute injury) emerged in a few regions, including the prefrontal and cerebellar cortices in SVHD over controls. In addition, male SVHD showed more brain changes over female SVHD.

conclusionsAdolescents with SVHD showed significant brain injury with variable male-female differences in areas that control cognition, anxiety, and depression, which may contribute to functional deficits found in the condition.

Indexed as

AdolescentAnxietyBrain InjuriesCognitive DysfunctionCross-Sectional StudiesDepressionFemaleHeart DiseasesHumansMaleSex Factorscingulatecongenital heart diseasehippocampusinsulamagnetic resonance imagingT2-relaxometry

Identifiers

PMID29315714
PMCPMC6103299
OpenAlexW2782943435

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.