Evidence map›Paper›PMID 29315624›Full record

ArticleAlcoholism, clinical and experimental research2018

Prenatal Alcohol Exposure Increases Histamine H

Rafael K Varaschin, Nyika A Allen, Martina J Rosenberg, C Fernando Valenzuela, Daniel D Savage

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The histamine HAlcohol (Fayetteville, N.Y.) · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rafael K VaraschinDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131.
Nyika A AllenDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131.
Martina J RosenbergDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131.
C Fernando ValenzuelaDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131.
Daniel D SavageDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131.ORCID 0000-0003-1726-1103
University of New Mexico · US

Funding

Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and interventionP20AA017068 · NIAAA · UNIVERSITY OF NEW MEXICO · PI SAVAGE, DANIEL D. · 2008 to 2012
$2.6M
Fetal Ethanol Effects on Histaminergic Regulation of NeurotransmissionR01AA019884 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SAVAGE, DANIEL D. · 2011 to 2015
$1.5M
NIAAA NIH HHS P20 AA017068NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R01 AA019884
6 · The paper itself

Abstract

backgroundWe have reported that prenatal alcohol exposure (PAE)-induced deficits in dentate gyrus, long-term potentiation (LTP), and memory are ameliorated by the histamine H

methodsLong-Evans rat dams voluntarily consumed either a 0% or 5% ethanol solution 4 hours each day throughout gestation. This pattern of drinking, which produces a mean peak maternal serum ethanol concentration of 60.8 ± 5.8 mg/dl, did not affect maternal weight gain, litter size, or offspring birthweight.

resultsRadiohistochemical studies in adult offspring revealed that specific [

conclusionsThese results suggest that a PAE-induced elevation in H

Indexed as

Prenatal Exposure Delayed EffectsAnimalsBiphenyl CompoundsCentral Nervous System DepressantsDentate GyrusEthanolFemaleGlutamic AcidGuanosine 5'-O-(3-Thiotriphosphate)Histamine AgonistsImidazolesMalePiperidinesPregnancyRatsRats, Long-EvansA349821Biphenyl CompoundsCentral Nervous System DepressantsEthanolGlutamic AcidGuanosine 5'-O-(3-Thiotriphosphate)Histamine AgonistsImidazolesmethimepipPiperidinesReceptors, Histamine H3Sulfur RadioisotopesTritiumDentate GyrusFetal Alcohol Spectrum DisorderGlutamateHistamine H3 ReceptorMethimepip

Identifiers

PMID29315624
PMCPMC5785429
OpenAlexW2772416935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.