Evidence map›Paper›PMID 29315574›Full record

ArticleJournal of neurochemistry2018

Palmitate-induced C/EBP homologous protein activation leads to NF-κB-mediated increase in BACE1 activity and amyloid beta genesis.

Gurdeep Marwarha, Jared Schommer, Jonah Lund, Trevor Schommer, Othman Ghribi

RetractedOpen access · greenAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Palmitic Acid-Induced NADNeurochemical research · 2019
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gurdeep MarwarhaDepartment of Biomedical Sciences, School of Medicine & Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.
Jared SchommerDepartment of Biomedical Sciences, School of Medicine & Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.
Jonah LundDepartment of Biomedical Sciences, School of Medicine & Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.
Trevor SchommerDepartment of Biomedical Sciences, School of Medicine & Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.
Othman GhribiDepartment of Biomedical Sciences, School of Medicine & Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.ORCID 0000-0002-4683-1286
University of North Dakota · US

Funding

Diets rich in palmitate increase Alzheimers disease risk by activating CHOP geneR01AG045264 · NIA · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2015 to 2019
$1.4M
NIA NIH HHS R01 AG045264
6 · The paper itself

Abstract

The etiology of Alzheimer's disease (AD) is egregiously comprehended, but epidemiological studies have posited that diets rich in the saturated fatty acid palmitic acid (palmitate) are a significant risk factor. The production and accumulation of amyloid beta peptide (Aβ) is considered the core pathological molecular event in the pathogenesis of AD. The rate-limiting step in Aβ genesis from amyloid-β precursor protein (AβPP) is catalyzed by the enzyme β-site amyloid precursor protein cleaving enzyme 1 (BACE1), the expression and enzymatic activity of which is significantly up-regulated in the AD brain. In this study, we determined the molecular mechanisms that potentially underlie the palmitate-induced up-regulation in BACE1 expression and augmented Aβ production. We demonstrate that a palmitate-enriched diet and exogenous palmitate treatment evoke an increase in BACE1 expression and activity leading to enhanced Aβ genesis in the mouse brain and SH-SY5Y-APP

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsApoptosisAspartic Acid EndopeptidasesCell Line, TumorGene Expression RegulationHumansMaleMice, Inbred C57BLNF-kappa BPalmitic AcidSignal TransductionTranscription Factor CHOPAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanBace1 protein, mouseDDIT3 protein, humanDdit3 protein, mouseNF-kappa BPalmitic AcidTranscription Factor CHOPAlzheimer's diseaseC/EBP homologous proteinendoplasmic reticulum stressnuclear factor of kappa-light-polypeptide gene enhancer of activated B cellspalmitic acidβ-site APP cleaving enzyme 1

Identifiers

PMID29315574
PMCPMC6371812
OpenAlexW2783261543

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.