ArticleSleep2018
Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis.
Article in Sleep, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 220 citations in OpenAlex.
- Validation of the STOP questionnaire as a screening tool for OSA among different populations: a systematic review and meta-regression analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Pooled it
- The Development of the European Sleep Questionnaire A New Patient-Reported Outcome Measure.Journal of sleep research · 2026Article
- Cardiovascular risk stratification in obstructive sleep apnea: a potential role for cardiac troponins.Sleep · 2026Article
- Sleepiness and attention in sleep-clinic patients and their associations with apnea severity and treatment.Sleep · 2026Article
- Mechanisms of upper airway muscle control in sleep reveal therapeutic targets for obstructive sleep apnea.American journal of respiratory cell and molecular biology · 2026Review
- Phenotyping of Obstructive Sleep Apnea Syndrome and Association with Cognitive Impairment, a Real-Life Study.Biomedicines · 2026Article
- Effect of Branched-Chain Amino Acid Supplementation Alone or Combined With Tryptophan or Methionine on Appetite Control and Related Health Outcomes in Older Adults: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Article
- Association Between Sleep Apnea Symptoms Subtypes and Obesity.Journal of clinical medicine · 2026Article
- Craniofacial and occlusal phenotypes associated with questionnaire-defined risk of sleep-disordered breathing in children: a cross-sectional study.BMC oral health · 2026Article
- Multimorbidity patterns in elderly sleep disordered breathing patients.ERJ open research · 2026Article
- Positive airway pressure therapy and cardiovascular events in obstructive sleep apnoea: an observational clinical cohort study.Sleep medicine · 2026Observational
- Severe obstructive sleep apnoea can be accurately diagnosed in primary care centres.NPJ primary care respiratory medicine · 2026Article
- Identification of Oral Protein Biomarkers for Cognitive Impairment Susceptibility in Obstructive Sleep Apnea: A Cross-Species Proteomic Study.ACS omega · 2026Article
- Clinical phenotypes of obstructive sleep apnea identified using cluster analysis.Respiratory research & clinical practice · 2026Article
- Multi-dimensional sleep patterns predict complications and mortality in chronic kidney disease patients: a prospective study from the UK Biobank.Frontiers in public health · 2026Article
- Clinical, polysomnographic, and psychological profiles across questionnaire-defined symptom groups in obstructive sleep apnea.Frontiers in medicine · 2026Article
- Respiratory event duration reveals novel phenotypes beyond the apnea-hypopnea index in obstructive sleep apnea.Frontiers in medicine · 2026Article
- Incretin-Based Therapies in Obesity-Related Obstructive Sleep Apnea: A Narrative Review of Evidence Tiers and Mechanistic Plausibility.Nature and science of sleep · 2026Review
- Beyond the apnea-hypopnea index: a call to action for a multidimensional evaluation in obstructive sleep apnea.Frontiers in sleep · 2026Article
- Clinical Phenotypes of Obstructive Sleep Apnea: A Decade of Evidence Toward Personalized Management.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
64 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 10 institutions in 7 countries.
Funding
Abstract
Study Objectives: A recent study of patients with moderate-severe obstructive sleep apnea (OSA) in Iceland identified three clinical clusters based on symptoms and comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the generalizability of OSA clusters in an international ethnically diverse cohort. Methods: Using data on 972 patients with moderate-severe OSA (apnea-hypopnea index [AHI] ≥ 15 events per hour) recruited from the Sleep Apnea Global Interdisciplinary Consortium (SAGIC), we performed a latent class analysis of 18 self-reported symptom variables, hypertension, cardiovascular disease, and diabetes. Results: The original OSA clusters of disturbed sleep, minimally symptomatic, and excessively sleepy replicated among 215 SAGIC patients from Iceland. These clusters also generalized to 757 patients from five other countries. The three clusters had similar average AHI values in both Iceland and the international samples, suggesting clusters are not driven by OSA severity; differences in age, gender, and body mass index were also generally small. Within the international sample, the three original clusters were expanded to five optimal clusters: three were similar to those in Iceland (labeled disturbed sleep, minimal symptoms, and upper airway symptoms with sleepiness) and two were new, less symptomatic clusters (labeled upper airway symptoms dominant and sleepiness dominant). The five clusters showed differences in demographics and AHI, although all were middle-aged (44.6-54.5 years), obese (30.6-35.9 kg/m2), and had severe OSA (42.0-51.4 events per hour) on average. Conclusions: Results confirm and extend previously identified clinical clusters in OSA. These clusters provide an opportunity for a more personalized approach to the management of OSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.