ArticlePloS one2018
Hyperphosphatemia is associated with high mortality in severe burns.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Association between blood phosphorus level and clinical outcomes in critically ill patients: A systematic review and meta-analysis.JPEN. Journal of parenteral and enteral nutrition · 2026Pooled it
- Hyperphosphatemia and Outcomes in Critically Ill Patients: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Meta-Analysis of Renal Replacement Therapy for Burn Patients: Incidence Rate, Mortality, and Renal Outcome.Frontiers in medicine · 2021Pooled it
- Association between serum phosphate levels and outcome among critically ill newborns: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Significance of Initial Serum Phosphate Imbalance in Traumatic Brain Injury with and Without Concomitant Spinal Injuries: Retrospective Analysis.Biomedicines · 2025Article
- Association between serum phosphate levels and 28-day mortality in patients with sepsis-associated liver injury: a cohort study.BMC infectious diseases · 2025Article
- Predictive value of physical and blood examination findings for short-term mortality in dogs with respiratory disorders.PloS one · 2025Article
- Serum phosphate levels and the development of sepsis associated acute kidney injury: evidence from two independent databases.Frontiers in medicine · 2024Article
- Hypo- and Hyperphosphatemia at Admission as Independent Factors of Mortality of COVID-19 Patients: Findings from a Retrospective Cohort Study.International journal of endocrinology and metabolism · 2022Article
- Association between early elevated phosphate and mortality among critically ill elderly patients: a retrospective cohort study.BMC geriatrics · 2022Article
- Association of Serum Phosphate Derangement With Mortality in Patients on Continuous Renal Replacement Therapy.Canadian journal of kidney health and disease · 2022Article
- Effect of Serum Phosphate on the Prognosis of Septic Patients: A Retrospective Study Based on MIMIC-IV Database.Frontiers in medicine · 2022Article
- Association between serum phosphate and mortality in critically ill patients: a large retrospective cohort study.BMJ open · 2021Article
- ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Impact of Admission Calcium-phosphate Product on 1-year Mortality among Hospitalized Patients.Advanced biomedical research · 2020Article
- Prognostic factors in patients with burns.Anaesthesiology intensive therapy · 2020Review
- Day-Specific Associations of Serum Phosphate With 90-Day Mortality in Adult Patients With sepsis: A Landmark Analysis.Acute medicine & surgeryArticle
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPhosphate level is often deranged during acute illness, regardless of the presence of kidney injury or not. A few studies described that hypophosphatemia may associated with outcome in patients admitted to the burn unit, but the literatures for hyperphosphatemia is limited. Our study aims to evaluate if hyperphosphatemia, one of the sign of severe tissue damage or kidney injury, will associate with mortality of patients with severe burns. MATERIALS AND
methodsThe study was a post hoc analysis of prospectively collected data from patients admitted to the burn unit between September 2006 and December 2011. Patients were stratified into normophosphatemic or hyperphosphatemic group by baseline plasma phosphate level. The primary endpoint is 90-day mortality.
resultsTotal 301 patients were included (hyperphosphatemia: n = 52; normophosphatemia: n = 249). The hyperphosphatemic group had lower Glasgow Coma Scale, mean arterial blood pressure, hemoglobin level, albumin, and higher TBSA of burns, APACHE II score, ABSI score, Acute kidney injury (AKI), and creatinine. The 90-day mortality was higher in the hyperphosphatemic group than in the normal group (53.8% vs 18.1%, P < .001) and this difference was still significant when adjusting for several confounding factors (hazard ratio, 2.05; 95% CI, 1.17-3.59). Multivariable Cox analysis showed risk factors of mortality included TBSA of burns, hyperphosphatemia, reduced urine output, and APACHE II score.
conclusionsOur study found in addition to TBSA of burns and inhalation injury, baseline hyperphosphatemia in patients with severe burns is also associated with higher mortality.
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