ArticlePloS one2018
Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04396522 (Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Using Body Composition Analysis for Improved Nutritional Intervention in Septic Patients: A Prospective Interventional Study.Nutrients · 2023Trial
- Fluid Balance is Associated with Differential Effects on Respiratory Failure between Critically Ill and Noncritically Ill Adults with SARS-CoV-2: a Retrospective Cohort Study.Shock (Augusta, Ga.) · 2026Article
- Percent fluid overload for prediction of fluid de-escalation in critically ill patients in Saudi Arabia: a prospective observational study.Acute and critical care · 2023Article
- A system theory based digital model for predicting the cumulative fluid balance course in intensive care patients.Frontiers in physiology · 2023Article
- The correlation between early net fluid balance and the clinical outcomes of patients receiving extracorporeal cardiopulmonary resuscitation.American journal of translational research · 2023Article
- Association of Hypernatremia with Immune Profiles and Clinical Outcomes in Adult Intensive Care Unit Patients with Sepsis.Biomedicines · 2022Article
- Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation.Biomedical journal · 2022Article
- Fluid Overload Phenotypes in Critical Illness-A Machine Learning Approach.Journal of clinical medicine · 2022Article
- A Positive Fluid Balance in the First Week Was Associated With Increased Long-Term Mortality in Critically Ill Patients: A Retrospective Cohort Study.Frontiers in medicine · 2022Article
- Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan.Journal of clinical medicine · 2021Article
- COVID-19-associated acute respiratory distress syndrome (CARDS): Current knowledge on pathophysiology and ICU treatment - A narrative review.Best practice & research. Clinical anaesthesiology · 2021Review
- Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study.Military Medical Research · 2021Article
- Examination of the association of steroids with fluid accumulation in critically ill patients, considering the possibility of biases.Scientific reports · 2021Article
- Impact of corticosteroid treatment on clinical outcomes of influenza-associated ARDS: a nationwide multicenter study.Annals of intensive care · 2020Article
- Article
- Incorporation of dynamic segmented neutrophil-to-monocyte ratio with leukocyte count for sepsis risk stratification.Scientific reports · 2019Observational
- Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care.Critical care (London, England) · 2019Article
- Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure.Scientific reports · 2018Article
- Impact of Early Fluid Balance on 1-Year Mortality in Critically Ill Patients With Cancer: A Retrospective Study in Central Taiwan.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
17 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluid balance is a fundamental management of patients with sepsis, and this study aimed to investigate the impact of cumulative fluid balance on critically ill patients with influenza admitted to an intensive care unit (ICU).
methodsThis multicenter retrospective cohort study was conducted by the Taiwan Severe Influenza Research Consortium (TSIRC) which includes eight medical centers. Patients with virology-proven influenza infection admitted to ICUs between October 2015 and March 2016 were included for analysis.
resultsA total of 296 patients were enrolled (mean age: 61.4±15.6 years; 62.8% men), and 92.2% (273/296) of them required mechanical ventilation. In the survivors, the daily fluid balance was positive from day 1 to day 3, and then gradually became negative from day 4 to day 7, whereas daily fluid balance was continuously positive in the non-survivors. Using the cumulative fluid balance from day 1-4 as a cut-off point, we found that a negative cumulative day 1-4 fluid balance was associated with a lower 30-day mortality rate (log-rank test, P = 0.003). To evaluate the impact of shock on this association, we divided the patients into shock and non-shock groups. The positive correlation between negative day 1-4 fluid balance and mortality was significant in the non-shock group (log-rank test, P = 0.008), but not in the shock group (log-rank test, P = 0.396). In a multivariate Cox proportional hazard regression model adjusted for age, sex, cerebrovascular disease, and PaO2/FiO2, day 1-4 fluid balance was independently associated with a higher 30-day mortality rate (aHR 1.088, 95% CI: 1.007-1.174).
conclusionsA negative day 1-4 cumulative fluid balance was associated with a lower mortality rate in critically ill patients with influenza. Our findings indicate the critical role of conservative fluid strategy in the management of patients with complicated influenza.
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