Evidence map›Paper›PMID 29315246›Full record

ReviewSensors (Basel, Switzerland)2018

Recent Advances in Electrochemical Biosensors Based on Enzyme Inhibition for Clinical and Pharmaceutical Applications.

Loubna El Harrad, Ilhame Bourais, Hasna Mohammadi, Aziz Amine

Open access · goldAbstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 134 citations in OpenAlex.

  1. Developing choline oxidase immobilization on CoBioprocess and biosystems engineering · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Loubna El HarradLaboratory of Process Engineering & Environment, Faculty of Sciences and Technology, Hassan II University of Casablanca, Mohammadia B.P.146, Morocco. elharrad.l@hotmail.fr.
Ilhame BouraisLaboratory of Process Engineering & Environment, Faculty of Sciences and Technology, Hassan II University of Casablanca, Mohammadia B.P.146, Morocco. ilhame_b@yahoo.com.
Hasna MohammadiLaboratory of Process Engineering & Environment, Faculty of Sciences and Technology, Hassan II University of Casablanca, Mohammadia B.P.146, Morocco. hasna2001fr@yahoo.fr.
Aziz AmineLaboratory of Process Engineering & Environment, Faculty of Sciences and Technology, Hassan II University of Casablanca, Mohammadia B.P.146, Morocco. a.amine@univh2m.ac.ma.
University of Hassan II Casablanca · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large number of enzyme inhibitors are used as drugs to treat several diseases such as gout, diabetes, AIDS, depression, Parkinson's and Alzheimer's diseases. Electrochemical biosensors based on enzyme inhibition are useful devices for an easy, fast and environment friendly monitoring of inhibitors like drugs. In the last decades, electrochemical biosensors have shown great potentials in the detection of different drugs like neostigmine, ketoconazole, donepezil, allopurinol and many others. They attracted increasing attention due to the advantage of being high sensitive and accurate analytical tools, able to reach low detection limits and the possibility to be performed on real samples. This review will spotlight the research conducted in the past 10 years (2007-2017) on inhibition based enzymatic electrochemical biosensors for the analysis of different drugs. New assays based on novel bio-devices will be debated. Moreover, the exploration of the recent graphical approach in diagnosis of reversible and irreversible inhibition mechanism will be discussed. The accurate and the fast diagnosis of inhibition type will help researchers in further drug design improvements and the identification of new molecules that will serve as new enzyme targets.

Indexed as

Biosensing TechniquesElectrochemical TechniquesEnzyme InhibitorsHumansEnzyme Inhibitorsdiagnosis of inhibitiondiseasedrugelectrochemical biosensorsenzyme inhibition

Identifiers

PMID29315246
PMCPMC5795370
OpenAlexW2783013781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.