ReviewBiology2018
Effects of Sex Steroids on Fish Leukocytes.
Review in Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 53 citations in OpenAlex.
- Altered immunometabolic responses to Aeromonas hydrophila infection in artificial diet-fed mandarin fish (Siniperca chuatsi).Fish physiology and biochemistry · 2026Article
- Diagnosis of Betanodavirus Infection in the Gonad of Greater Amberjack Broodstocks Shows a Sex-Biased Infection and Immune Responses.Microbial ecology · 2026Article
- Fishy factors: recognizing biological variation and its implications for fish immuno(eco)toxicology research.Environmental toxicology and chemistry · 2025Article
- Proteins journey-from marine to freshwater ecosystem: blood plasma proteomic profiles of pink salmonFrontiers in physiology · 2023Article
- Integrated Omics Approaches Revealed the Osmotic Stress-Responsive Genes and Microbiota in Gill of Marine Medaka.mSystems · 2022Article
- Synthetic Progestins in Waste and Surface Waters: Concentrations, Impacts and Ecological Risk.Toxics · 2022Review
- Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes-Review.International journal of molecular sciences · 2022Review
- Multi-Approach Assessment for Stress Evaluation in Rainbow Trout Females,Animals : an open access journal from MDPI · 2021Article
- Epidermal Club Cells in Fishes: A Case for Ecoimmunological Analysis.International journal of molecular sciences · 2021Review
- The intersection of stress, sex and immunity in fishes.Immunogenetics · 2021Review
- 17β-Estradiol affects the innate immune response in common carp.Fish physiology and biochemistry · 2020Article
- Netting the Stress Responses in Fish.Frontiers in endocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vertebrates, in addition to their classically reproductive functions, steroids regulate the immune system. This action is possible mainly due to the presence of steroid receptors in the different immune cell types. Much evidence suggests that the immune system of fish is vulnerable to xenosteroids, which are ubiquitous in the aquatic environment. In vivo and in vitro assays have amply demonstrated that oestrogens interfere with both the innate and the adaptive immune system of fish by regulating the main leukocyte activities and transcriptional genes. They activate nuclear oestrogen receptors and/or G-protein coupled oestrogen receptor. Less understood is the role of androgens in the immune system, mainly due to the complexity of the transcriptional regulation of androgen receptors in fish. The aim of this manuscript is to review our present knowledge concerning the effect of sex steroid hormones and the presence of their receptors on fish leukocytes, taking into consideration that the studies performed vary as regard the fish species, doses, exposure protocols and hormones used. Moreover, we also include evidence of the probable role of progestins in the regulation of the immune system of fish.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.