Evidence map›Paper›PMID 29315209›Full record

ArticleMarine drugs2018

The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling.

Liang-Mou Kuo, Po-Jen Chen, Ping-Jyun Sung, Yu-Chia Chang, Chun-Ting Ho, Yi-Hsiu Wu, Tsong-Long Hwang

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Methanol Extract ofAntioxidants (Basel, Switzerland) · 2022
    Article
  6. Methanol Extract ofAntioxidants (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Biochemical and Immunological implications of Lutein and Zeaxanthin.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Marine drugs · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Apoptotic effects of hsian-tsao (Food science & nutrition · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Liang-Mou KuoGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. kuo33410@yahoo.com.tw.
Po-Jen ChenGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. litlep@hotmail.com.
Ping-Jyun SungGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.ORCID 0000-0002-6644-9236
Yu-Chia ChangNational Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jay0404@gmail.com.
Chun-Ting HoGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. Tsudanyer@hotmail.com.
Yi-Hsiu WuGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. modemtw@gmail.com.
Tsong-Long HwangGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.ORCID 0000-0002-5780-3977
Chang Gung University · TWChang Gung University of Science and Technology · TWNational Sun Yat-sen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral

Indexed as

AnimalsAnthozoaApoptosisCaspase 3Cell LineCell SurvivalExtracellular Signal-Regulated MAP KinasesHepatic Stellate CellsJNK Mitogen-Activated Protein KinasesRatsReactive Oxygen SpeciesSignal TransductionSterolsCaspase 3Extracellular Signal-Regulated MAP KinasesJNK Mitogen-Activated Protein Kinasespinnigorgiol AReactive Oxygen SpeciesSterolsapoptosiscaspase-3hepatic stellate cellsMAPKPinnigorgia sp.ROS

Identifiers

PMID29315209
PMCPMC5793067
OpenAlexW2783384736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.