Evidence map›Paper›PMID 29315079›Full record

Trial reportAging2018

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.

Claudia Schwarz, Slaven Stekovic, Miranka Wirth, Gloria Benson, Philipp Royer, Stephan J Sigrist, Thomas Pieber, Christopher Dammbrueck, Christoph Magnes, Tobias Eisenberg and 5 more

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02755246 (Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline), which is not on this map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02755246 phase2completednot on this map

Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2016 to 2016Enrolled30ConditionsSubjective Cognitive DeclineArmsPolyamine supplementation, Placebo supplementation
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 150 citations in OpenAlex.

  1. Trial
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  3. SAT1-Induced Spermidine Depletion Potentiates Food Allergy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Claudia Schwarz *Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.
Slaven Stekovic *Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Miranka Wirth *Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.
Gloria BensonCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.
Philipp RoyerInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Stephan J SigristCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Cluster of Excellence, Berlin, Germany.
Thomas PieberBioTechMed, Graz, Austria.
Christopher DammbrueckInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Christoph MagnesJoanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria.
Tobias EisenbergInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Tobias PendlInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Jens BohlkenMedical Practice Bohlken for Neurology and Psychiatry, Berlin, Germany.
Theresa KöbeCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.
Frank MadeoInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Agnes FlöelDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Nawi Graz · ATCharité - Universitätsmedizin Berlin · DEHumboldt-Universität zu Berlin · DEJoanneum Research · ATUniversity of Graz · ATBioTechMed-Graz · ATFreie Universität Berlin · DEUniversitätsmedizin Greifswald · DE

Funding

Austrian Science Fund FWF P 27893Austrian Science Fund FWF P 29203
6 · The paper itself

Abstract

Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models. The present translational study aimed to determine safety and tolerability of a wheat germ extract containing enhanced spermidine concentrations. In a preclinical toxicity study, supplementation of spermidine using this extract did not result in morbidities or changes in behavior in BALBc/Rj mice during the 28-days repeated-dose tolerance study. Post mortem examination of the mice organs showed no increase in tumorigenic and fibrotic events. In the human cohort (participants with subjective cognitive decline, n=30, 60 to 80 years of age), a 3-month randomized, placebo-controlled, double-blind Phase II trial was conducted with supplementation of the spermidine-rich plant extract (dosage: 1.2 mg/day). No differences were observed between spermidine and placebo-treated groups in vital signs, weight, clinical chemistry and hematological parameters of safety, as well as in self-reported health status at the end of intervention. Compliance rates above 85% indicated excellent tolerability. The data demonstrate that spermidine supplementation using a spermidine-rich plant extract is safe and well-tolerated in mice and older adults. These findings allow for longer-term intervention studies in humans to investigate the impact of spermidine treatment on cognition and brain integrity.

Indexed as

Administration, OralAgedAged, 80 and overAgingAnimalsCognitionCognitive DysfunctionDouble-Blind MethodFemaleHumansMaleMiceMice, Inbred BALB CMiddle AgedPlant ExtractsSpermidinePlant ExtractsSpermidineagingdietary supplementpolyaminessafetyspermidinesubjective cognitive decline

Identifiers

PMID29315079
PMCPMC5807086
OpenAlexW2783296044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.