Evidence map›Paper›PMID 29314863›Full record

ArticleAmerican journal of respiratory cell and molecular biology2018

Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease.

Bradley W Richmond, Rui-Hong Du, Wei Han, John T Benjamin, Riet van der Meer, Linda Gleaves, Marshall Guo, Austin McKissack, Yongqin Zhang, Dong-Sheng Cheng and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The Role ofChronic obstructive pulmonary diseases (Miami, Fla.) · 2025
    Article
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  11. Article
  12. Article
  13. Article
  14. An update in club cell biology and its potential relevance to chronic obstructive pulmonary disease.American journal of physiology. Lung cellular and molecular physiology · 2023
    Review
  15. Article
  16. Article
  17. Smoking-induced microbial dysbiosis in health and disease.Clinical science (London, England : 1979) · 2022
    Review
  18. Secretory Cells Are the Primary Source of pIgR in Small Airways.American journal of respiratory cell and molecular biology · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Bradley W Richmond1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Rui-Hong Du1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Wei Han1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
John T Benjamin2 Department of Pediatrics, Division of Neonatology.
Riet van der Meer2 Department of Pediatrics, Division of Neonatology.
Linda Gleaves1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Marshall Guo1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Austin McKissack1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Yongqin Zhang1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Dong-Sheng Cheng1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Vasiliy V Polosukhin1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Timothy S Blackwell1 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine.
Pulmonary and Allergy Associates · US

Funding

Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Interdisciplinary Training Program in Lung ResearchT32HL094296 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ray Stokes Peebles · 2008 to 2026
$6.3M
Role of p73 in COPD PathogenesisK08HL138088 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHMOND, BRADLEY WINSTON · 2017 to 2018
$317k
Mechanisms driving airway inflammation in chronic lung diseaseI01BX002378 · VA · VETERANS HEALTH ADMINISTRATION · PI Timothy S. Blackwell · 2014 to 2026
–
BLRD VA I01 BX002378NHLBI NIH HHS K08 HL138088NHLBI NIH HHS T32 HL094296NICHD NIH HHS K12 HD043483
6 · The paper itself

Abstract

Loss of secretory IgA is common in the small airways of patients with chronic obstructive pulmonary disease and may contribute to disease pathogenesis. Using mice that lack secretory IgA in the airways due to genetic deficiency of polymeric Ig receptor (pIgR

Indexed as

Airway RemodelingAminopyridinesAnimalsBacillusBenzamidesCyclopropanesDisease Models, AnimalMice, Inbred C57BLMice, Mutant StrainsNeutrophilsPneumonia, BacterialPulmonary Disease, Chronic ObstructivePulmonary EmphysemaReceptors, Cell SurfaceAminopyridinesBenzamidesCyclopropanesOscar protein, mouseReceptors, Cell SurfaceRoflumilastchronic obstructive pulmonary diseaseemphysemamucosal immunitypolymeric Ig receptorsecretory IgA

Identifiers

PMID29314863
PMCPMC6002662
OpenAlexW2783415057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.