ArticleCNS neuroscience & therapeutics2018
Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome.
Article in CNS neuroscience & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Mechanisms of Changma Xifeng tablet in alleviating Tourette syndrome via modulation of neurotransmitters, inflammatory responses, and metabolic pathways.Frontiers in psychiatry · 2026Article
- Elucidating the material basis and therapeutic mechanisms of Shaoma Zhijing granules for tourette syndrome by UPLC/Q-TOF-MS and multiple models.Metabolic brain disease · 2025Article
- Striking long-term beneficial effects of single dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming.Molecular psychiatry · 2025Article
- Striking Long Term Beneficial Effects of Single Dose Psilocybin and Psychedelic Mushroom Extract in the SAPAP3 Rodent Model of OCD-Like Excessive Self-Grooming.bioRxiv : the preprint server for biology · 2024Article
- The Sapap3Translational psychiatry · 2023Article
- Structural analyses in the study of behavior: From rodents to non-human primates.Frontiers in psychology · 2022Review
- Qinglong Zhidong Decoction Alleviated Tourette Syndrome in MiceFrontiers in pharmacology · 2022Article
- Effects of Different Anxiety Levels on the Behavioral Patternings Investigated through T-pattern Analysis in Wistar Rats Tested in the Hole-Board Apparatus.Brain sciences · 2021Article
- Possible Contribution of T-pattern Detection and Analysis to the Study of the Behavioral Correlates of Afferent Inhibition.Brain sciences · 2020Article
- Treatment of tics associated with Tourette syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Combining Quantitative and Qualitative Data in the Study of Feeding Behavior in Male Wistar Rats.Frontiers in psychology · 2019Article
- Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome.CNS neuroscience & therapeutics · 2018Article
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8 authors.
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Abstract
aimThe transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS.
methodsThe behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed. Analyses of transition probabilities among behaviors further provided an overall picture of the behavioral dynamics.
resultsT-patterns and transition matrices revealed in D1CT-7 mice a clear-cut hyperactivity compared to controls, with a lower behavioral organization and a marked shift from cautious sniffing toward locomotion. Moreover, the behavioral patterns of the transgenic mice were pervasively disturbed by intrusive tic-like HBT leading to a marked fragmentation of the behavior. Novel exposure to open field provoked a transient inhibitory control over the disrupting phenotype.
conclusionThe results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS.
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