Evidence map›Paper›PMID 29314709›Full record

ArticleJournal of biophotonics2018

A frequency-domain non-contact photoacoustic microscope based on an adaptive interferometer.

Deepu George, Harriet Lloyd, Ronald H Silverman, Parag V Chitnis

Registry-linked trialAbstract read
In one paragraph

Article in Journal of biophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06060925 (Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06060925 completednot on this mapstarted 2023, after this paper: background citation

Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain

TypeobservationalSponsorGeorge Mason UniversityRan2023 to 2025Enrolled96ConditionsMyofascial Pain Syndrome, HealthyArmsUltrasound imaging, Bioimpedance spectroscopy, Electromyography, Physical examination
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Molecular and cellular imaging of the eye.Biomedical optics express · 2024
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Deepu GeorgeDepartment of Bioengineering, George Mason University, Fairfax, Virginia.
Harriet LloydEdward S Harkness Eye Institute, Columbia University Medical Center, New York, New York.
Ronald H SilvermanEdward S Harkness Eye Institute, Columbia University Medical Center, New York, New York.
Parag V ChitnisDepartment of Bioengineering, George Mason University, Fairfax, Virginia.ORCID 0000-0003-0845-5619

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
Holography-based Photoacoustic Imaging of the RetinaR21EY023012 · NEI · RIVERSIDE RESEARCH INSTITUTE · PI CHITNIS, PARAG VIJAY · 2013 to 2014
$419k
NEI NIH HHS P30 EY019007NEI NIH HHS R21 EY023012
6 · The paper itself

Abstract

A frequency-domain, non-contact approach to photoacoustic microscopy (PAM) that employs amplitude-modulated (0.1-1 MHz) laser for excitation (638-nm pump) in conjunction with a 2-wave mixing interferometer (532-nm probe) for non-contact detection of photoacoustic waves at the specimen surface is presented. A lock-in amplifier is employed to detect the photoacoustic signal. Illustrative images of tissue-mimicking phantoms, red-blood cells and retinal vasculature are presented. Single-frequency modulation of the pump beam directly provides an image that is equivalent to the 2-dimensional projection of the image volume. Targets located superficially produce phase modulations in the surface-reflected probe beam due to surface vibrations as well as direct intensity modulation in the backscattered probe light due to local changes in pressure and/or temperature. In comparison, the observed modulations in the probe beam due to targets located deeper in the specimen, for example, beyond the ballistic photon regime, predominantly consist of phase modulation.

Indexed as

ErythrocytesHumansInterferometryMicroscopyMicrovesselsPhantoms, ImagingPhotoacoustic TechniquesRetinainterferometrymicroscopyphotoacoustic imagingphotorefractive crystal

Identifiers

PMID29314709
PMCPMC6746176

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.