Evidence map›Paper›PMID 29314626›Full record

ReviewInternational wound journal2018

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery.

Lohrasb R Sayadi, Derek A Banyard, Mary E Ziegler, Zaidal Obagi, Jordyne Prussak, Michael J Klopfer, Gregory Rd Evans, Alan D Widgerow

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International wound journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05169814 (Micro/Nanobubbles), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05169814 early_phase1recruitingnot on this mapstarted 2021, after this paper: background citation

Micro/Nanobubbles (MNBs) and Wound Therapy: A Pilot Study Involving a Novel Oxygen Delivery System for Treatment of Acute and Chronic Wounds

TypeinterventionalSponsorUniversity of California, IrvineRan2021 to 2027Enrolled40ConditionsOpen Wound, Wound HealArmsMicro/nanobubble (MNB) - Irrigation, 0.9% Normal Saline - Irrigation, Micro/nanobubble (MNB) - Negative Pressure Wound Therapy with Instillation (NPWTi), 0.9% Normal Saline - Negative Pressure Wound Therapy with Instillation (NPWTi)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lohrasb R SayadiCenter for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.
Derek A BanyardCenter for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.
Mary E ZieglerCenter for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.
Zaidal ObagiCenter for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.
Jordyne PrussakCenter for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.
Michael J KlopferBiomedical Engineering Department, University of California, Irvine, California.
Gregory Rd EvansCenter for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.
Alan D WidgerowCenter for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to 15 billion dollars of US health care expenditure each year is consumed by treatment of poorly healing wounds whose etiologies are often associated with aberrancies in tissue oxygenation. To address this issue, several modes of tissue oxygen delivery systems exist, including Hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT), but their efficacies have yet to be fully substantiated. Micro/nanobubbles (MNBs), which range anywhere from 100 μm to <1 μm in diameter and are relatively stable for hours, offer a new mode of oxygen delivery to wounds. The aim of this article is to systematically review literature examining the use of TOT for wound healing and use of MNBs for tissue oxygenation using the MEDLINE database. The search yielded 87 articles (12 MNB articles and 75 TOT articles), of which 52 met the inclusion criteria for this literature review (12 MNB articles and 40 TOT articles). Additionally, we present an analysis on the efficacy of our MNB generating technology and propose its use as a wound healing agent.

Indexed as

Hyperbaric OxygenationWound HealingAdministration, TopicalHumansOxygenWounds and InjuriesOxygenmicro/nanobubblesnanobubblestissue oxygenationtopical oxygen therapywound healing

Identifiers

PMID29314626
PMCPMC7950116

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.