Evidence map›Paper›PMID 29314349›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018

Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies.

Jingjing Gao, Xiaochi Liu, Hatice Secinti, Ziwen Jiang, Oyuntuya Munkhbat, Yisheng Xu, Xuhong Guo, S Thayumanavan

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Multichannel dual protein sensing using amphiphilic supramolecular assemblies.Chemical communications (Cambridge, England) · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Programmed Degradation of Hydrogels with a Double-Locked Domain.Angewandte Chemie (International ed. in English) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingjing GaoDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Xiaochi LiuDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Hatice SecintiDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Ziwen JiangDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Oyuntuya MunkhbatDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Yisheng XuState-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Xuhong GuoState-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
S ThayumanavanDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.ORCID http://orcid.org/0000-0002-6475-6726

Funding

New Amphiphillic Dendrimers for Encapsulation and ReleaseR01GM065255 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THAYUMANAVAN, SANKARAN · 2003 to 2019
$4.3M
NIGMS NIH HHS R01 GM065255
6 · The paper itself

Abstract

Specific response to the concurrent presence of two different inputs is one of the hallmarks of incorporating specificities in nature. Artificial nanoassemblies that concurrently respond to two very different inputs are of great interest in a variety of applications, especially in biomedicine. Here, we present a design strategy for amphiphilic nanoassemblies with such capabilities, enabled by photocaging a ligand moiety that is capable of binding to a specific protein. New molecular designs that offer nanoassemblies that respond to either of two inputs or only to the concurrent presence of two inputs are outlined. Such biomimetic nanoassemblies could find use in many applications, including drug delivery and diagnostics.

Indexed as

dual inputshost-guest transformationphotoactivationstimulus-responsive nanoassembliessupramolecular disassembly

Identifiers

PMID29314349
PMCPMC6192416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.