Evidence map›Paper›PMID 29314250›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2018

Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification.

Justin N Williams, Anuradha Valiya Kambrath, Roshni B Patel, Kyung Shin Kang, Elsa Mével, Yong Li, Ying-Hua Cheng, Austin J Pucylowski, Mariah A Hassert, Michael J Voor and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

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  17. An Improved Methodology to Evaluate Cell and Molecular Signals in the Reparative Callus During Fracture Healing.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
    Article
  18. Sonic Hedgehog Regulates Bone Fracture Healing.International journal of molecular sciences · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Justin N WilliamsDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Anuradha Valiya KambrathDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Roshni B PatelDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Kyung Shin KangDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Elsa MévelDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Yong LiDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Ying-Hua ChengDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Austin J PucylowskiDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Mariah A HassertDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Michael J VoorDepartment of Orthopaedic Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
Melissa A KacenaDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
William R ThompsonDepartment of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA.
Stuart J WardenDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
David B BurrDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Matthew R AllenDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexander G RoblingDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Uma SankarDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USIndiana University IndianapolisJuliana Kinderziekenhuis · NLSaint Louis University · USUniversity of Louisville · US

Funding

Lrp5 signaling in bone mechanotransduction and metabolismR01AR053237 · NIAMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ALEXANDER G ROBLING, Matthew L Warman · 2005 to 2026
$9.4M
Comprehensive Training Program in Musculoskeletal ResearchT32AR065971 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ALEXANDER G ROBLING · 2015 to 2026
$4.4M
CaMKK2 Inhibition as a Dual-Action Bone Anabolic and Anti-Catabolic Therapy in OsteoporosisR01AR068332 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SANKAR, UMA · 2015 to 2019
$2.1M
SkyScan 1176 Micro CT SystemS10OD016208 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI WILLIAMS, JAMES C · 2014 to 2014
$383k
Lrp5 and Lrp6 signaling in bone mechanotransduction and metabolismR56AR053237 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ROBLING, ALEXANDER G, WARMAN, MATTHEW L · 2023 to 2023
$349k
BLRD VA I01 BX001478NIAMS NIH HHS R01 AR053237NIAMS NIH HHS R01 AR068332NIAMS NIH HHS R56 AR053237NIAMS NIH HHS T32 AR065971NIH HHS S10 OD016208
6 · The paper itself

Abstract

Approximately 10% of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient bone healing. Inhibition of Ca

Indexed as

AnimalsBenzimidazolesBony CallusCalcium-Calmodulin-Dependent Protein Kinase KinaseCollagen Type IFracture HealingHedgehog ProteinsMaleMiceNaphthalimidesOsteogenesisSignal TransductionBenzimidazolesCalcium-Calmodulin-Dependent Protein Kinase KinaseCamkk2 protein, mouseCollagen Type IHedgehog Proteinsihh protein, mouseNaphthalimidesSTO 609ANABOLICSANIMAL MODELSINJURY/FRACTURE HEALINGORTHOPAEDICSPRECLINICAL STUDIESTHERAPEUTICS

Identifiers

PMID29314250
PMCPMC6549722
OpenAlexW2781834742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.