ArticleMuscle & nerve2018
Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk.
Article in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Early life events may be the first steps on the multistep path to amyotrophic lateral sclerosis.Scientific reports · 2024Article
- Exposure to Metals, Pesticides, and Air Pollutants: Focus on Resulting DNA Methylation Changes in Neurodegenerative Diseases.Biomolecules · 2024Review
- What does scientometry tell us about mercury toxicology and its biological impairments?Heliyon · 2024Article
- Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.Annals of neurology · 2024Review
- Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study.medRxiv : the preprint server for health sciences · 2024Article
- Article
- The amyotrophic lateral sclerosis exposome: recent advances and future directions.Nature reviews. Neurology · 2023Review
- Prevalence of amyotrophic lateral sclerosis in the United States using established and novel methodologies, 2017.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2023Article
- Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry-funded Research.Annals of clinical and translational neurology · 2022Article
- A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk.Journal of neurology · 2022Review
- Amyotrophic Lateral Sclerosis Risk, Family Income, and Fish Consumption Estimates of Mercury and Omega-3 PUFAs in the United States.International journal of environmental research and public health · 2021Article
- AMPA receptor contribution to methylmercury-mediated alteration of intracellular CaNeurotoxicology · 2020Article
- Epigenetic influence of environmentally neurotoxic metals.Neurotoxicology · 2020Review
- Keratinous biomarker of mercury exposure associated with amyotrophic lateral sclerosis risk in a nationwide U.S. study.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020Article
- Novel Insights into Mercury Effects on Hemoglobin and Membrane Proteins in Human Erythrocytes.Molecules (Basel, Switzerland) · 2020Article
- Phenol-RichAntioxidants (Basel, Switzerland) · 2019Article
- Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer RiskAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Article
- A Comparison of Mercury Exposure from Seafood Consumption and Dental Amalgam Fillings in People with and without Amyotrophic Lateral Sclerosis (ALS): An International Online Case-Control Study.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
introductionMercury is a neurotoxic metal that is potentially a risk factor for amyotrophic lateral sclerosis (ALS). Consumption of methylmercury contaminated fish is the primary source of US population exposure to mercury.
methodsWe used inductively coupled plasma mass spectrometry to measure levels of mercury in toenail samples from patients with ALS (n = 46) and from controls (n = 66) as a biomarker of mercury exposure.
resultsPatients with ALS had higher toenail mercury levels (odds ratio 2.49, 95% confidence interval 1.18-5.80, P = 0.024) compared with controls, adjusted for age and sex. We also estimated the amount of mercury consumed from finfish and shellfish and found toenail mercury levels elevated overall among patients with ALS and controls in the top quartile for consumption (P = 0.018). DISCUSSION: Biomarker data show that ALS is associated with increased with mercury levels, which were related to estimated methylmercury intake via fish. Replication of these associations in additional populations is warranted. Muscle Nerve, 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.