Evidence map›Paper›PMID 29313975›Full record

ArticleInternational journal of cancer2018

Near-infrared photoimmunotherapy targeting EGFR-Shedding new light on glioblastoma treatment.

Thomas A Burley, Justyna Mączyńska, Anant Shah, Wojciech Szopa, Kevin J Harrington, Jessica K R Boult, Anna Mrozek-Wilczkiewicz, Maria Vinci, Jeffrey C Bamber, Wojciech Kaspera and 1 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 66 citations in OpenAlex.

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  11. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Thomas A BurleyDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Justyna MączyńskaDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Anant ShahDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Wojciech SzopaDepartment of Neurosurgery, Medical University of Silesia, Regional Hospital, Sosnowiec, Poland.
Kevin J HarringtonDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Jessica K R BoultDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Anna Mrozek-WilczkiewiczA. Chelkowski Institute of Physics, University of Silesia, Katowice, Poland.
Maria VinciDepartment of Onco-Hematology, Bambino Gesù Children's Hospital, Rome, Italy.
Jeffrey C BamberDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Wojciech KasperaDepartment of Neurosurgery, Medical University of Silesia, Regional Hospital, Sosnowiec, Poland.
Gabriela Kramer-MarekDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-8053-3880
Institute of Cancer Research · GBMedical University of Silesia · PLBambino Gesù Children's Hospital · ITUniversity of Silesia in Katowice · PL

Funding

Cancer Research UK 16464Cancer Research UK C1060/A16464
6 · The paper itself

Abstract

Glioblastomas (GBMs) are high-grade brain tumors, differentially driven by alterations (amplification, deletion or missense mutations) in the epidermal growth factor receptor (EGFR), that carry a poor prognosis of just 12-15 months following standard therapy. A combination of interventions targeting tumor-specific cell surface regulators along with convergent downstream signaling pathways may enhance treatment efficacy. Against this background, we investigated a novel photoimmunotherapy approach combining the cytotoxicity of photodynamic therapy with the specificity of immunotherapy. An EGFR-specific affibody (Z

Indexed as

ImmunotherapyPhototherapyAnimalsAntineoplastic Agents, ImmunologicalCell DeathCell Line, TumorDisease Models, AnimalErbB ReceptorsFemaleGlioblastomaHumansImmunoconjugatesMiceMolecular ImagingXenograft Model Antitumor AssaysAntineoplastic Agents, ImmunologicalErbB ReceptorsImmunoconjugatesaffibody moleculesEGFRglioblastomaphotoimmunotherapy

Identifiers

PMID29313975
PMCPMC6016485
OpenAlexW2782886926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.