ArticleNature communications2017
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 7 pooled it
16.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
132 citing papers in PubMed, 7 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.EBioMedicine · 2026Pooled it
- Reviewing the association between motor competence and physical activity from a behavioral genetic perspective.Frontiers in psychology · 2025Pooled it
- The phenotypic and genotypic association of grip strength with frailty, physical performance and functional limitations over time in older adults.Age and ageing · 2023Pooled it
- Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis.Communications biology · 2023Pooled it
- Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.Nature communications · 2021Pooled it
- Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.BMJ (Clinical research ed.) · 2018Pooled it
- The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance.American journal of human genetics · 2018Pooled it
- Impact of Different Isokinetic Movement Patterns on Shoulder Rehabilitation Outcome.International journal of environmental research and public health · 2022Trial
- DNA methylation signatures in skeletal muscle associated with physical function in healthy older adults.GeroScience · 2026Article
- Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice.Aging cell · 2026Article
- Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and Its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts.Medicine and science in sports and exercise · 2026Article
- Integrative GWAS Catalog Analysis of Proxy-Trait Intersection in Sarcopenia-Related Musculoskeletal Aging with Multi-Criteria Evidence Integration.Life (Basel, Switzerland) · 2026Article
- From Athletic Performance to Functional Ageing: Shared Genetic Architecture, Redox-Inflammatory Pathways and Functional Reserve Across the Life Course-A Narrative Review.Biomedicines · 2026Review
- Contribution of Sport Type to the Association Between Handgrip Strength and Morbidity/Mortality: Future Follow-up Study and Possible Mechanisms.Sports medicine - open · 2026Review
- Article
- Multi-Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ-Specific Aging Clocks.Aging cell · 2026Review
- Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders.Nature communications · 2026Article
- A genomic structural equation modelling study elucidates shared genetic architecture of polygenic traits associated with post-intensive care syndrome.Scientific reports · 2026Article
- Polygenic Associations Between Motor Behavior, Neuromotor Traits, and Active Music Engagement in Four Cohorts.Annals of the New York Academy of Sciences · 2026Article
- Largely Distinct Post-Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging.Journal of cachexia, sarcopenia and muscle · 2026Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
77 authors at 20 institutions in 18 countries.
Sara M WillemsMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
Daniel J WrightMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.ORCID 0000-0003-3983-2093
Felix R DayMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.ORCID 0000-0003-3789-7651
Katerina TrajanoskaDepartment of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
Peter K JoshiUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK.ORCID 0000-0002-6361-5059
John A MorrisCentre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada QC H3T 1E2.ORCID 0000-0003-2769-8202
Amy M MatteiniDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Fleur C GartonQueensland Brain Institute, University of Queensland, St Lucia, Queensland 4072, Australia.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Nikolay OskolkovLund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skånes University Hospital, 222 41 Lund, Sweden.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2031, Australia.
Massimo ManginoDepartment of Twin Research &Genetic Epidemiology, Kings College London, London SE1 7EH, UK.ORCID 0000-0002-2167-7470
Jun LiuDepartment of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
Ayse DemirkanDepartment of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
Monkol LekAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Maryland 02114, USA.
Liwen XuAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Maryland 02114, USA.
Guan WangCentre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Eastbourne BN20 7SN, UK.
Christopher OldmeadowHunter Medical Research Institute, Newcastle, New South Wales 2305, Australia.
Kyle J GaultonDepartment of Pediatrics, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0003-1318-7161
Luca A LottaMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
Eri Miyamoto-MikamiJapan Society for the Promotion of Science, Tokyo 102-0083, Japan.
Manuel A RivasDepartment of Biomedical Data Sciences, Stanford University, Stanford, California 94305, USA.
Tom WhiteMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.ORCID 0000-0001-8456-0803
Po-Ru LohBROAD Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Mette AadahlResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, DK-2600 Glostrup, Denmark.
Najaf AminDepartment of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
John R AttiaHunter Medical Research Institute, Newcastle, New South Wales 2305, Australia.
Krista AustinCentre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Eastbourne BN20 7SN, UK.
Beben BenyaminQueensland Brain Institute, University of Queensland, St Lucia, Queensland 4072, Australia.
Søren BrageMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
Yu-Ching ChengDivision of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Paweł CięszczykFaculty of Physical Education, Gdańsk University of Physical Education and Sport, 80-336 Gdańsk, Poland.
Wim DeraveDepartment of Movement and Sports Sciences, Ghent University, 9000 Ghent, Belgium.
Karl-Fredrik ErikssonLund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skånes University Hospital, 222 41 Lund, Sweden.
Nir EynonInstitute of Sport, Exercise &Active Living (ISEAL), Victoria University, Melbourne, Victoria 8001, Australia.ORCID 0000-0003-4046-8276
Allan LinnebergResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, DK-2600 Glostrup, Denmark.ORCID 0000-0002-0994-0184
Alejandro LuciaUniversidad Europea de Madrid, 28670 Villaviciosa de Odón, Madrid, Spain.
Myosotis MassiddaDepartment of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.ORCID 0000-0001-5726-4435
Braxton D MitchellDivision of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Motohiko MiyachiNational Institutes of Biomedical Innovation, Health and Nutrition, Tokyo 162-8636, Japan.ORCID 0000-0002-1146-0905
Haruka MurakamiNational Institutes of Biomedical Innovation, Health and Nutrition, Tokyo 162-8636, Japan.
Sandosh PadmanabhanBritish Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Ashutosh PandeyTarget Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
Ioannis PapadimitriouInstitute of Sport, Exercise &Active Living (ISEAL), Victoria University, Melbourne, Victoria 8001, Australia.
Deepak K RajpalTarget Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
Craig SaleMusculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University, Nottingham NG1 4FQ, UK.
Theresia M SchnurrThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-6573-4959
Francesco SessaDepartment of Clinical and Experimental Medicine, Medical Genetics, University of Foggia, 71122 Foggia FG, Italy.
Nick ShrineDepartment of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0003-3641-4371
Martin D TobinDepartment of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0002-3596-7874
Ian VarleyMusculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University, Nottingham NG1 4FQ, UK.
Louise V WainDepartment of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0003-4951-1867
Naomi R WrayQueensland Brain Institute, University of Queensland, St Lucia, Queensland 4072, Australia.
Cecilia M LindgrenBROAD Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Daniel G MacArthurAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Maryland 02114, USA.
Dawn M WaterworthTarget Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
Mark I McCarthyWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Douglas P KielHarvard Medical School, Boston, Maryland 02115, USA.
GEFOS Any-Type of Fracture Consortium
Yannis PitsiladisCentre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Eastbourne BN20 7SN, UK.
Noriyuki FukuGraduate School of Health and Sports Science, Juntendo University, Chiba 270-1695, Japan.
Paul W FranksGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Skånes University Hospital, 222 41 Lund, Sweden.
Kathryn N NorthMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2031, Australia.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Ola HanssonLund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skånes University Hospital, 222 41 Lund, Sweden.ORCID 0000-0002-7394-7639
Tim SpectorDepartment of Twin Research &Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Joanne M MurabitoBoston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA.
J Brent RichardsCentre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada QC H3T 1E2.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands.ORCID 0000-0001-9435-9441
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
John R B PerryMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
Nick J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.
University of Cambridge · GBErasmus MC · NLBroad Institute · USUniversity of Copenhagen · DKUniversity of Tartu · EECalifornia Pacific Medical Center · USHarvard University · USLund University · SEBoston University · USdeCODE Genetics (Iceland) · ISIcelandic Heart Association · ISJewish General Hospital · CAKing's College London · GBLeiden University Medical Center · NLOregon Health & Science University · USTampere University · FITarget (United States) · USThe University of Queensland · AUTranslational Research Institute · AUUniversity of Brighton · GB
Funding
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MRISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MIntegrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3MGenetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic GroupsU01HG004436 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2008 to 2009
$1.1MOsteocalcin and Metabolic Risk Factors. The Framingham StudyR21AR056405 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI HSU, YI-HSIANG · 2010 to 2011
$377kCancer Research UK 14136Medical Research Council G0401527Medical Research Council G0902313Medical Research Council G1000143Medical Research Council MC_QA137853Medical Research Council MC_U106179473Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/3Medical Research Council MR/N003284/1Medical Research Council MR/N011317/1NCATS NIH HHS UL1 TR002369NHGRI NIH HHS U01 HG004436NHLBI NIH HHS R01 HL105756NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R21 AR056405NIA NIH HHS U24 AG051129NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK072488Wellcome Trust
Abstract
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10
Indexed as
Genetics, PopulationGenome-Wide Association StudyHand StrengthActinsAdultAgedCohort StudiesFemaleGenetic LociHandHumansMaleMembrane ProteinsMiddle AgedNeoplasm ProteinsNuclear ProteinsACTG1 protein, humanActinsLRPPRC protein, humanMembrane ProteinsNeoplasm ProteinsNSL1 protein, humanNuclear ProteinsPEX14 protein, humanRepressor ProteinsTGFA protein, humanTransforming Growth Factor alpha
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