Evidence map›Paper›PMID 29313800›Full record

ArticleeLife2018

KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring.

Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G Chaudhary, Mohammed H Al-Qahtani, Nobutaka Hirokawa

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Non-transport functions of motor proteins in corticogenesis.Frontiers in cell and developmental biology · 2026
    Review
  4. Article
  5. Review
  6. Research progress of kinesin family in neurological diseases.Frontiers in cellular neuroscience · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. KIF2A deficiency causes early-onset neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Review
  14. Kinesins in Mammalian Spermatogenesis and Germ Cell Transport.Frontiers in cell and developmental biology · 2022
    Review
  15. Article
  16. Article
  17. Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Noriko HommaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1322-9993
Ruyun ZhouDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Muhammad Imran NaseerCenter of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Adeel G ChaudharyCenter of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Mohammed H Al-QahtaniCenter of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Nobutaka HirokawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0081-5264
King Abdulaziz University · SAThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. KIF2A mutations have recently been identified in patients with malformed cortical development. However, postnatal KIF2A is continuously expressed in the hippocampus, in which new neurons are generated throughout an individual's life in established neuronal circuits. In this study, we investigated KIF2A function in the postnatal hippocampus by using tamoxifen-inducible

Indexed as

AnimalsCell MovementCell ProliferationGene Expression RegulationGene Knockout TechniquesHippocampusKinesinsMiceMice, KnockoutNeuronsRepressor ProteinsKIF2A protein, mouseKinesinsRepressor Proteinsaxon-dendrite determinationcell biologydentate granule cellE. coliKIF2Amouseneurosciencepostnatal hippocampal wiringtemporal lobe epilepsy

Identifiers

PMID29313800
PMCPMC5811213
OpenAlexW2782814233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.